Kang Chenglin, Liu Peng, Liu Yue, Zeng Xianhai, Zhao Hailiang, Qiu Shuqi, Liu Jiangqi
Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041; Department of Otorhinolaryngology, Longgang Otorhinolaryngology Hospital, Shenzhen Institute of Otorhinolaryngology, Shenzhen 518172; Department of Otorhinolaryngology, The Second People's Hospital of Gansu Province, Lanzhou 730000, China.
Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041; Department of Otorhinolaryngology, Longgang Otorhinolaryngology Hospital, Shenzhen Institute of Otorhinolaryngology, Shenzhen 518172, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024 May;40(5):460-464.
Allergic rhinitis (AR), a common disease in otolaryngology, is a key risk factor for poorly controlled asthma and many complications, although it is not life-threatening. The negative impact of AR on social productive forces and human health is no less than that of asthma. Dendritic cells (DCs) play an important role in AR. In addition to sharing some of DC's biological characteristics, DCs-derived exosomes (DEXs) can promote the priming and activation of T cells and the maturation and differentiation of T helper type 2 (Th2) cells. Multiple signaling pathways in AR can be modulated by DEXs, which present allergens and participate in allergic immune responses. Anti-allergic drugs can be carried by DEXs to alleviate allergic airway inflammation and treat Th2-mediated AR effectively. Therefore, DEXs are crucial in the pathogenesis and treatment of AR.
变应性鼻炎（AR）是耳鼻咽喉科的一种常见疾病，虽然它不会危及生命，但却是哮喘控制不佳和许多并发症的关键危险因素。AR对社会生产力和人类健康的负面影响不亚于哮喘。树突状细胞（DCs）在AR中起重要作用。除了具有一些DC的生物学特性外，DC来源的外泌体（DEXs）还可以促进T细胞的致敏和激活以及2型辅助性T细胞（Th2）的成熟和分化。AR中的多种信号通路可被DEXs调节，DEXs呈递变应原并参与变应性免疫反应。抗过敏药物可通过DEXs携带，以减轻变应性气道炎症并有效治疗Th2介导的AR。因此，DEXs在AR的发病机制和治疗中至关重要。
