BRIC, BoRdeaux Institute of onCology, UMR 1312, Inserm, Université de Bordeaux, 33000 Bordeaux, France.
Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut P.O. Box 17-5208, Lebanon.
Genes (Basel). 2024 May 17;15(5):635. doi: 10.3390/genes15050635.
Primary cutaneous lymphomas (PCLs) are a heterogeneous group of lymphoproliferative disorders caused by the accumulation of neoplastic T or B lymphocytes in the skin. Sézary syndrome (SS) is an aggressive and rare form of cutaneous T cell lymphoma (CTCL) characterized by an erythroderma and the presence of atypical cerebriform T cells named Sézary cells in skin and blood. Most of the available treatments for SS are not curative, which means there is an urgent need for the development of novel efficient therapies. Recently, targeting cancer metabolism has emerged as a promising strategy for cancer therapy. This is due to the accumulating evidence that metabolic reprogramming highly contributes to tumor progression. Genes play a pivotal role in regulating metabolic processes, and alterations in these genes can disrupt the delicate balance of metabolic pathways, potentially contributing to cancer development. In this review, we discuss the importance of targeting energy metabolism in tumors and the currently available data on the metabolism of Sézary cells, paving the way for potential new therapeutic approaches aiming to improve clinical outcomes for patients suffering from SS.
原发性皮肤淋巴瘤（PCL）是一组异质性的淋巴增殖性疾病，由皮肤中肿瘤性 T 或 B 淋巴细胞的积累引起。蕈样肉芽肿病（SS）是一种侵袭性和罕见的皮肤 T 细胞淋巴瘤（CTCL），其特征为红皮病和皮肤及血液中存在异常脑回样 T 细胞，称为蕈样细胞。大多数 SS 的现有治疗方法并非治愈性的，这意味着迫切需要开发新型有效的治疗方法。最近，靶向癌症代谢已成为癌症治疗的一种有前途的策略。这是因为越来越多的证据表明，代谢重编程对肿瘤进展有很大贡献。基因在调节代谢过程中起着关键作用，这些基因的改变可能会破坏代谢途径的微妙平衡，从而有可能促进癌症的发展。在这篇综述中，我们讨论了靶向肿瘤能量代谢的重要性，以及目前关于蕈样细胞代谢的可用数据，为旨在改善 SS 患者临床结局的潜在新治疗方法铺平了道路。
