Department of Public Health, Yonsei University Graduate School, Seoul, Republic of Korea; Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
J Affect Disord. 2018 Oct 1;238:8-15. doi: 10.1016/j.jad.2018.05.012. Epub 2018 May 28.
The effects of skeletal muscle mass on depressive symptoms remain poorly understood, especially in the middle-aged population. We examined the relationship between skeletal muscle mass and depressive symptoms according to sex and menopausal status in the middle-aged Korean population.
Herein, 1,151 men and 2,176 women aged 30-64 years completed questionnaires and underwent health examinations in the Cardiovascular and Metabolic Disease Etiology Research Center study. Appendicular skeletal muscle mass (ASM) was measured via bioelectrical impedance analysis and adjusted for height squared (ASM/Ht). Both continuous values and tertile groups of ASM/Ht were used for analysis. Depressive symptoms were assessed using the Beck Depressive Inventory-II (BDI), and the prevalence of depressive symptoms was determined as a BDI score ≥ 20.
Multiple logistic regression analysis using a fully adjusted model showed that depressive symptoms were more frequently observed among men in the lower ASM/Ht tertile and middle ASM/Ht tertile than among those in the higher ASM/Ht tertile. Each 1-kg/m decrease in ASM/Ht was significantly associated with the presence of depressive symptoms in men. Such significant association was not observed among premenopausal and postmenopausal women.
The cross-sectional nature of the study design, measurement of skeletal muscle mass and depressive symptoms only once, estimation of skeletal muscle mass using bioelectrical impedance analysis, assessing depressive symptoms by self-reported questionnaire, and potential unknown confounding variables constitute the limitations of our study.
The independent association between low skeletal muscle mass and depressive symptoms was observed in men but not in women.
骨骼肌量与抑郁症状之间的关系仍不清楚，尤其是在中年人群中。我们根据性别和绝经状态，在韩国中年人群中研究了骨骼肌量与抑郁症状之间的关系。
在此，30-64 岁的 1151 名男性和 2176 名女性完成了问卷调查并接受了心血管和代谢疾病病因学研究中心的体检。通过生物电阻抗分析测量四肢骨骼肌量（ASM），并根据身高的平方进行调整（ASM/Ht）。我们使用 ASM/Ht 的连续值和三分位组进行分析。使用贝克抑郁量表第二版（BDI）评估抑郁症状，BDI 评分≥20 为存在抑郁症状。
使用完全调整模型的多因素逻辑回归分析显示，与高 ASM/Ht 三分位组相比，低 ASM/Ht 三分位组和中 ASM/Ht 三分位组的男性中抑郁症状更为常见。ASM/Ht 每降低 1kg/m，男性出现抑郁症状的风险显著增加。这种显著相关性在绝经前和绝经后女性中并未观察到。
本研究设计为横断面研究，仅测量一次骨骼肌量和抑郁症状，使用生物电阻抗分析估计骨骼肌量，通过自我报告的问卷评估抑郁症状，以及可能存在未知的混杂变量，这些都构成了本研究的局限性。
低骨骼肌量与抑郁症状之间的独立关联仅在男性中观察到，而在女性中未观察到。
