Wu Dong, Cheng Ming, Yi Xiangzhou, Xia Guanghua, Liu Zhongyuan, Shi Haohao, Shen Xuanri
School of Food Science and Engineering, Hainan University, Haikou 570228, China.
Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Haikou 570228, China.
Foods. 2024 May 7;13(10):1431. doi: 10.3390/foods13101431.
Food-borne bioactive peptides have shown promise in preventing and mitigating alcohol-induced liver injury. This study was the first to assess the novel properties of peptides (MCPs) in mitigating acute alcoholic liver injury in mice, and further elucidated the underlying mechanisms associated with this effect. The results showed that MCPs can improve lipid metabolism by modulating the AMPK signaling pathway, decreasing fatty acid synthase activity, and increasing carnitine palmitoyltransferase 1a activity. Meanwhile, MCPs ameliorate inflammation by inhibiting the NF-κB activation, leading to reduced levels of pro-inflammatory cytokines (tumor necrosis factor-α and interleukin-1β). Additionally, a 16S rDNA sequencing analysis revealed that MCPs can restore the balance of gut microbiota and increase the relative abundance of beneficial bacteria. These findings suggest that supplementation of MCPs could attenuate alcohol intake-induced acute liver injury, and, thus, may be utilized as a functional dietary supplement for the successful treatment and prevention of acute liver injury.
食源生物活性肽在预防和减轻酒精性肝损伤方面已显示出前景。本研究首次评估了肽（MCPs）减轻小鼠急性酒精性肝损伤的新特性，并进一步阐明了与此效应相关的潜在机制。结果表明，MCPs可通过调节AMPK信号通路、降低脂肪酸合酶活性和增加肉碱棕榈酰转移酶1a活性来改善脂质代谢。同时，MCPs通过抑制NF-κB激活来减轻炎症，从而导致促炎细胞因子（肿瘤坏死因子-α和白细胞介素-1β）水平降低。此外，16S rDNA测序分析显示，MCPs可恢复肠道微生物群的平衡并增加有益细菌的相对丰度。这些发现表明，补充MCPs可减轻酒精摄入引起的急性肝损伤，因此，可作为一种功能性膳食补充剂用于成功治疗和预防急性肝损伤。
