Guerra Ana, Belinha Jorge, Salgado Christiane, Monteiro Fernando Jorge, Natal Jorge Renato
INEGI-Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial, 4200-465 Porto, Portugal.
ISEP-Instituto Superior de Engenharia do Porto, Departamento de Engenharia Mecânica, Politécnico do Porto, Rua Dr. António Bernardino de Almeida, 431, 4249-015 Porto, Portugal.
Biomedicines. 2024 May 9;12(5):1045. doi: 10.3390/biomedicines12051045.
This study employs a meshless computational model to investigate the impacts of compression and traction on angiogenesis, exploring their effects on vascular endothelial growth factor (VEGF) diffusion and subsequent capillary network formation. Three distinct initial domain geometries were defined to simulate variations in endothelial cell sprouting and VEGF release. Compression and traction were applied, and the ensuing effects on VEGF diffusion coefficients were analysed. Compression promoted angiogenesis, increasing capillary network density. The reduction in the VEGF diffusion coefficient under compression altered VEGF concentration, impacting endothelial cell migration patterns. The findings were consistent across diverse simulation scenarios, demonstrating the robust influence of compression on angiogenesis. This computational study enhances our understanding of the intricate interplay between mechanical forces and angiogenesis. Compression emerges as an effective mediator of angiogenesis, influencing VEGF diffusion and vascular pattern. These insights may contribute to innovative therapeutic strategies for angiogenesis-related disorders, fostering tissue regeneration and addressing diseases where angiogenesis is crucial.
本研究采用无网格计算模型来研究压缩和牵引对血管生成的影响，探讨它们对血管内皮生长因子（VEGF）扩散及随后的毛细血管网络形成的作用。定义了三种不同的初始域几何形状，以模拟内皮细胞发芽和VEGF释放的变化。施加了压缩和牵引，并分析了其对VEGF扩散系数的后续影响。压缩促进了血管生成，增加了毛细血管网络密度。压缩下VEGF扩散系数的降低改变了VEGF浓度，影响了内皮细胞迁移模式。在不同的模拟场景中结果都是一致的，表明压缩对血管生成有强大的影响。这项计算研究增进了我们对机械力与血管生成之间复杂相互作用的理解。压缩成为血管生成的有效调节因子，影响VEGF扩散和血管模式。这些见解可能有助于为血管生成相关疾病制定创新治疗策略，促进组织再生并解决血管生成至关重要的疾病。
