Dębniak Tadeusz, Baszuk Piotr, Duchnik Ewa, Rowińska Karolina, Rogoża-Janiszewska Emilia, Boer Magdalena, Kiedrowicz Magdalena, Marchlewicz Mariola, Watola Daniel, Feherpataky Martyna, Derkacz Róża, Dębniak Anna, Marciniak Wojciech, Gołębiewska Katarzyna, Lubiński Jan, Scott Rodney J, Gronwald Jacek
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, 71-252 Szczecin, Poland.
Department of Skin Diseases and Venerology, Pomeranian Medical University, 72-010 Police, Poland.
Biomedicines. 2024 May 13;12(5):1082. doi: 10.3390/biomedicines12051082.
Using an Inductively Coupled Plasma Mass Spectrometer we measured the concentration of selenium and arsenic in serum and blood samples from 336 unselected psoriatic patients and 336 matched healthy controls to evaluate any associations with the clinical course of the disease. We genotyped 336 patients and 903 matched controls to evaluate the prevalence of (rs4880), (rs1001179), (rs1050450), and (rs921943) polymorphisms using Taqman assays. The mean selenium (Se) level in serum was 74 µg/L in patients and 86 µg/L in controls ( < 0.001). The mean Se level in blood was 95 µg/L in patients and 111 µg/L in controls ( < 0.001). Psoriasis risk was greatest among participants with the lowest serum (<68.75 µg/L, OR: 8.30; < 0.001) and lowest blood concentrations of Se (<88.04 µg/L, OR: 10.3; < 0.001). Similar results were observed in subgroups of males and females. We found an inverse correlation of selenium levels with PASI, NAPSI, and BSA scores. There was no significant difference in the distribution of the , , , and polymorphisms. Among carriers of rs4880, rs1001179, and rs921943 polymorphisms, blood selenium levels were significantly lower. The mean arsenic level in serum was 0.79 µg/L in patients and 0.7 µg/L in controls ( = 0.2). The mean concentration in blood was 1.1 µg/L in patients and 1.3 µg/L in controls ( < 0.001). In conclusion, we found that lower selenium levels, in blood and serum, are associated with psoriasis risk and its more severe course. Future prospective studies should focus on the optimalisation of the concentration of this trace element not only for prophylactic guidance but also to support the treatment of this disease.
我们使用电感耦合等离子体质谱仪测量了336例未经挑选的银屑病患者以及336例匹配的健康对照者血清和血液样本中硒和砷的浓度，以评估其与疾病临床进程的任何关联。我们对336例患者和903例匹配的对照者进行基因分型，使用Taqman分析方法评估（rs4880）、（rs1001179）、（rs1050450）和（rs921943）多态性的患病率。患者血清中硒（Se）的平均水平为74μg/L，对照者为86μg/L（P<0.001）。患者血液中硒的平均水平为95μg/L，对照者为111μg/L（P<0.001）。血清硒水平最低（<68.75μg/L，比值比：8.30；P<0.001）和血液中硒浓度最低（<88.04μg/L，比值比：10.3；P<0.001）的参与者患银屑病的风险最高。在男性和女性亚组中观察到类似结果。我们发现硒水平与银屑病面积和严重程度指数（PASI）、指甲银屑病严重程度指数（NAPSI）和体表面积（BSA）评分呈负相关。（rs4880）、（rs1001179）、（rs1050450）和（rs921943）多态性的分布没有显著差异。在rs4880、rs1001179和rs921943多态性的携带者中，血液硒水平显著较低。患者血清中砷的平均水平为0.79μg/L，对照者为0.7μg/L（P=0.2）。患者血液中的平均浓度为1.1μg/L，对照者为1.3μg/L（P<0.001）。总之，我们发现血液和血清中较低的硒水平与银屑病风险及其更严重的病程相关。未来的前瞻性研究应不仅关注该微量元素浓度的优化以提供预防指导，还应支持该疾病的治疗。
