窄谱中波紫外线光疗治疗银屑病患者血清中硒、锌、铜、Cu/Zn 比值、总抗氧化状态和 C-反应蛋白的浓度：一项病例对照研究。

Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: A case-control study.

机构信息

Laboratory of Cosmetology, Medical University of Bialystok, Akademicka 3 St., 15-267 Bialystok, Poland.

Department of Bromatology, Medical University of Bialystok,Mickiewicza 2D St., 15-222 Bialystok, Poland.

出版信息

J Trace Elem Med Biol. 2017 Dec;44:109-114. doi: 10.1016/j.jtemb.2017.06.008. Epub 2017 Jun 27.

DOI:10.1016/j.jtemb.2017.06.008

PMID:28965564

Abstract

BACKGROUND

Psoriasis is a common, an inflammatory skin disease. Trace elements may play an active role in the pathogenesis of psoriasis.

OBJECTIVE

The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) and c-reactive protein (CRP) in the serum of patients with psoriasis.

METHODS

In this case-control study sixty patients with psoriasis and fifty-eight healthy people were examined. Serum levels of Se, Zn and Cu were determined by atomic absorption spectrometry. Cu/Zn ratio was calculated. TAS was measured spectrophotometrically. CRP was analyzed by immunoturbidimetric method. Clinical activity of psoriasis was evaluated using Psoriasis Area and Severity Index (PASI).

RESULTS

Serum concentration of Se in patients with psoriasis (71.89±16.90μg/L) was lower as compared to the control group (79.42±18.97μg/L) and after NB-UVB. Cu level of patients was higher (1.151±0.320mg/L) as compared to controls (1.038±0.336mg/L), but Zn level did not differ. We observed higher Cu/Zn ratio (p<0.05) in examined patients than in the control group and after NB-UVB. We found decrease TAS before and after NB-UVB. CRP levels was found to be normal range. A significant correlation coefficient between CRP and Cu/Zn was observed.

CONCLUSIONS

The study showed some disturbances in the serum levels of trace elements and TAS in psoriatic patients.

摘要

背景

银屑病是一种常见的炎症性皮肤病。微量元素可能在银屑病的发病机制中发挥积极作用。

目的

本研究旨在评估银屑病患者血清中硒（Se）、锌（Zn）、铜（Cu）和铜/锌比值以及总抗氧化状态（TAS）和 C 反应蛋白（CRP）的浓度。

方法

在这项病例对照研究中，检查了 60 名银屑病患者和 58 名健康人。采用原子吸收光谱法测定血清 Se、Zn 和 Cu 水平。计算铜/锌比值。TAS 通过分光光度法测量。CRP 采用免疫比浊法分析。采用银屑病面积和严重程度指数（PASI）评估银屑病的临床活动。

结果

银屑病患者血清 Se 浓度（71.89±16.90μg/L）低于对照组（79.42±18.97μg/L）和 NB-UVB 后，Cu 水平高于对照组（1.151±0.320mg/L），但 Zn 水平无差异。与对照组和 NB-UVB 后相比，我们观察到检查患者的 Cu/Zn 比值更高（p<0.05）。我们发现 TAS 在 NB-UVB 前后均降低。CRP 水平处于正常范围。观察到 CRP 和 Cu/Zn 之间存在显著的相关系数。