乳清蛋白分离物作为设计花提取物控释材料的基质。

Whey Protein Isolate as a Substrate to Design Flower Extract Controlled-Release Materials.

机构信息

Faculty of Chemistry, Nicolaus Copernicus University in Torun, ul. Gagarina 7, 87-100 Torun, Poland.

School of Engineering, Lancaster University, Lancaster LA1 4YW, UK.

出版信息

Int J Mol Sci. 2024 May 13;25(10):5325. doi: 10.3390/ijms25105325.

Abstract

The use of natural active substances and the development of new formulations are promising directions in the cosmetic and pharmacy industries. The primary purpose of this research was the production of microparticles based on whey protein isolate (WPI) and calcium alginate (ALG) containing flower extract and their incorporation into films composed of gelatin, WPI, and glycerol. Both swollen and dry microparticles were studied by optical microscopy and their sizes were measured. Water absorption by the microparticles, their loading capacity, and the release profile of flower extract were also characterized. The films were analyzed by mechanical tests (Young's modulus, tensile strength, elongation at break), swelling capacity, contact angle, and moisture content measurements. The presented data showed that the active ingredient was successfully enclosed in spherical microparticles and completely released after 75 min of incubation at 37 °C. The incorporation of the microparticles into polymer films caused a decrease in stiffness and tensile strength, simultaneously increasing the ductility of the samples. Moreover, the films containing microparticles displayed higher swelling ability and moisture content compared to those without them. Hence, the materials prepared in this study with flower extract encapsulated into polymeric microspheres can be a starting point for the development of new products intended for skin application; advantages include protection of the extract against external factors and a controlled release profile.

摘要

天然活性物质的应用和新制剂的开发是化妆品和制药行业的有前途的方向。本研究的主要目的是生产基于乳清蛋白分离物(WPI)和海藻酸钠(ALG)的微球,其中含有花提取物,并将其掺入由明胶、WPI 和甘油组成的薄膜中。通过光学显微镜研究了溶胀和干燥的微球,并测量了它们的尺寸。还对微球的吸水率、载药量和花提取物的释放曲线进行了表征。通过机械测试(杨氏模量、拉伸强度、断裂伸长率)、溶胀能力、接触角和水分含量测量对薄膜进行了分析。所提供的数据表明,活性成分成功地包裹在球形微球中,并在 37°C 孵育 75 分钟后完全释放。将微球掺入聚合物薄膜中会降低刚性和拉伸强度,同时增加样品的延展性。此外,与不含微球的薄膜相比,含有微球的薄膜具有更高的溶胀能力和水分含量。因此,本研究中用花提取物包封在聚合物微球中的材料可以作为开发用于皮肤应用的新产品的起点;其优点包括保护提取物免受外部因素的影响和控制释放曲线。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8eb/11120854/7707e1881ca7/ijms-25-05325-g001.jpg

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