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卵丘-卵母细胞复合体的电代谢偶联。

Electro-Metabolic Coupling of Cumulus-Oocyte Complex.

机构信息

Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via dell'Elce di Sotto 8, 06132 Perugia, Italy.

Laboratorio Interdipartimentale di Fisiopatologia della Riproduzione, Università degli Studi di Perugia, Edificio C, Piano 3 P.zza Lucio Severi, 1, Sant'Andrea delle Fratte, 06132 Perugia, Italy.

出版信息

Int J Mol Sci. 2024 May 14;25(10):5349. doi: 10.3390/ijms25105349.

DOI:10.3390/ijms25105349
PMID:38791387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11120766/
Abstract

Oocyte-cumulus cell interaction is essential for oocyte maturation and competence. The bidirectional crosstalk network mediated by gap junctions is fundamental for the metabolic cooperation between these cells. As cumulus cells exhibit a more glycolytic phenotype, they can provide metabolic substrates that the oocyte can use to produce ATP via oxidative phosphorylation. The impairment of mitochondrial activity plays a crucial role in ovarian aging and, thus, in fertility, determining the success or failure of assisted reproductive techniques. This review aims to deepen the knowledge about the electro-metabolic coupling of the cumulus-oocyte complex and to hypothesize a putative role of potassium channel modulators in order to improve fertility, promote intracellular Ca influx, and increase the mitochondrial biogenesis and resulting ATP levels in cumulus cells.

摘要

卵母细胞-卵丘细胞相互作用对于卵母细胞的成熟和能力至关重要。间隙连接介导的双向信号转导网络对于这些细胞之间的代谢合作至关重要。由于卵丘细胞表现出更具糖酵解表型，它们可以提供代谢底物，卵母细胞可以通过氧化磷酸化利用这些底物来产生 ATP。线粒体活性的损伤在卵巢衰老中起着关键作用，因此也决定了辅助生殖技术的成败。本综述旨在深入了解卵丘-卵母细胞复合体的电代谢偶联，并假设钾通道调节剂可能具有一定的作用，以提高生育能力、促进细胞内 Ca2+内流、增加卵丘细胞的线粒体生物发生和由此产生的 ATP 水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7159/11120766/38901cf9608f/ijms-25-05349-g006.jpg
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