Department of Translational Research and New Technologies, University of Pisa, 56126 Pisa, Italy.
Department of Medicine, Surgery and Health Sciences, University of Trieste, 56126 Trieste, Italy.
Int J Mol Sci. 2023 Feb 26;24(5):4562. doi: 10.3390/ijms24054562.
Bladder cancer is the most common tumor of the urinary system, with a high incidence in the male population. Surgery and intravesical instillations can eradicate it, although recurrences are very common, with possible progression. For this reason, adjuvant therapy should be considered in all patients. Resveratrol displays a biphasic dose response both in vitro and in vivo (intravesical application) with an antiproliferative effect at high concentrations and antiangiogenic action in vivo (intraperitoneal application) at a low concentration, suggesting a potential role for it in clinical management as an adjuvant to conventional therapy. In this review, we examine the standard therapeutical approach to bladder cancer and the preclinical studies that have investigated resveratrol in xenotransplantation models of bladder cancer. Molecular signals are also discussed, with a particular focus on the STAT3 pathway and angiogenic growth factor modulation.
膀胱癌是泌尿系统最常见的肿瘤，男性发病率较高。手术和膀胱内灌注可以根除它，尽管复发非常常见，可能会进展。因此，应考虑对所有患者进行辅助治疗。白藜芦醇在体外和体内（膀胱内应用）均表现出双相剂量反应，高浓度时具有抗增殖作用，低浓度时在体内（腹腔内应用）具有抗血管生成作用，提示其在临床管理中作为常规治疗的辅助药物具有潜在作用。在这篇综述中，我们检查了膀胱癌的标准治疗方法和研究白藜芦醇在膀胱癌异种移植模型中的临床前研究。还讨论了分子信号，特别关注 STAT3 途径和血管生成生长因子的调节。
