Chen Ya-Mei, Wu Jia-Ling, Lin Wei-Hao
College of Veterinary Medicine, National Pingtung University of Science and Technology, Neipu, Pingtung County 912301, Taiwan.
Animals (Basel). 2024 May 15;14(10):1469. doi: 10.3390/ani14101469.
Compared to the number of studies on the neoplasms of laboratory rodents, fewer studies have focused on spontaneous neoplasms in pet rodents. Notably, the mouse mammary tumor virus (MMTV) is associated with mammary tumors in rodents. In this study, 77 tumors and tumor-like lesions of biopsy samples were collected from 70 pet rodents, including hamsters (n = 47), guinea pigs (n = 16), unknown species (n = 4), rats (n = 2), and a gerbil. Fifty tumors were collected from 47 hamsters, in which the most common tumors were mammary tumors (13/50), followed by fibrosarcoma (9/50), mast cell tumors (4/50), and squamous cell carcinoma (4/50). The collected subtypes of mammary tumors in hamsters included tubular carcinoma (n = 5), tubular adenoma (n = 4), carcinoma and malignant myoepithelioma (n = 1), simple tubular carcinoma (n = 1), adenosquamous carcinoma (n = 1), and tubulopapillary adenoma (n = 1). In addition, twenty tumors were collected from guinea pigs, in which the most common tumor was lipoma (6/20), followed by adenocarcinoma of the mammary gland (4/20), trichofolliculoma (2/20), and collagenous hamartomas (2/20). In guinea pigs, the subtypes of mammary gland tumors were tubular carcinoma (n = 2), tubular and solid carcinoma (n = 1), and tubulopapillary carcinoma (n = 1). In 20 cases of mammary tumors, MMTV was not detected, implicating no evidence of MMTV infection in mammary oncogenesis in pet rodents in Taiwan.
与关于实验啮齿动物肿瘤的研究数量相比，针对宠物啮齿动物自发性肿瘤的研究较少。值得注意的是，小鼠乳腺肿瘤病毒（MMTV）与啮齿动物的乳腺肿瘤有关。在本研究中，从70只宠物啮齿动物收集了77个活检样本的肿瘤和肿瘤样病变，包括仓鼠（n = 47）、豚鼠（n = 16）、未知物种（n = 4）、大鼠（n = 2）和一只沙鼠。从47只仓鼠中收集了50个肿瘤，其中最常见的肿瘤是乳腺肿瘤（13/50），其次是纤维肉瘤（9/50）、肥大细胞瘤（4/50）和鳞状细胞癌（4/50）。仓鼠乳腺肿瘤的收集亚型包括管状癌（n = 5）、管状腺瘤（n = 4）、癌和恶性肌上皮瘤（n = 1）、单纯管状癌（n = 1）、腺鳞癌（n = 1）和管状乳头状腺瘤（n = 1）。此外，从豚鼠中收集了20个肿瘤，其中最常见的肿瘤是脂肪瘤（6/20），其次是乳腺腺癌（4/20）、毛发滤泡瘤（2/20）和胶原性错构瘤（2/20）。在豚鼠中，乳腺肿瘤的亚型是管状癌（n = 2）、管状和实性癌（n = 1）以及管状乳头状癌（n = 1）。在20例乳腺肿瘤中，未检测到MMTV，这表明台湾宠物啮齿动物乳腺肿瘤发生中没有MMTV感染的证据。
