Lebednikaitė Eglė, Sutkevičienė Neringa, Vilkonienė Toma, Balčiauskienė Žana, Kučinskas Kęstutis, Anskienė Lina, Pockevičius Alius
Department of Veterinary Pathobiology, Faculty of Veterinary Medicine, Lithuanian University of Health Sciences, Tilzes 18, 47181 Kaunas, Lithuania.
Animal Reproduction Laboratory, Large Animal Clinic, Faculty of Veterinary Medicine, Lithuanian University of Health Sciences, Tilzes 18, 47181 Kaunas, Lithuania.
Animals (Basel). 2024 May 17;14(10):1499. doi: 10.3390/ani14101499.
Wooden breast (WB) myopathy is a pathology of the muscle. Wooden breast is caused by multiple factors. The exact etiopathogenesis of this myodegenerative pathology is still unclear. Fast-growing commercial lines of broilers that are selected for high breast muscle yields are more susceptible to this myopathy. The biochemical analysis of blood is used to diagnose pathologies and understand disease processes. Therefore, the objective of this research was to determine and compare the changes in the blood serum biochemical parameters of Ross 308 chicken broilers without myopathy and those affected by WB myopathy. Blood samples were collected from male and female Ross 308 broilers that were 43 days old, with an average live weight of 2.98-3.09 kg. Representative blood samples were selected from broilers with WB ( = 33) and without WB ( = 33). In the laboratory, the blood was centrifugated, and biochemical tests were performed with an automated computerized biochemistry analyzer. The research results showed that broilers with WB had elevated blood serum levels of creatine kinase (CK) ( = 0.018), potassium ( = 0.010), and alanine aminotransferase (ALT) ( = 0.012). In conclusion, elevated serum levels of CK and potassium indicated that skeletal muscle cells were damaged. Moreover, increased ALT levels suggested a possible association between WB myopathy and liver damage. Additionally, these research findings underscore the diagnostic significance of CK and hint at its potential as a WB biomarker.
木胸肌病是一种肌肉病理学病症。木胸肌病由多种因素引起。这种肌肉退行性病变的确切病因仍不清楚。为获得高胸肌产量而选育的快速生长型商业肉鸡品系更容易患这种肌病。血液生化分析用于诊断病症并了解疾病进程。因此,本研究的目的是确定并比较未患肌病的罗斯308肉鸡和受木胸肌病影响的罗斯308肉鸡血清生化参数的变化。从43日龄、平均活重2.98 - 3.09千克的罗斯308雌雄肉鸡中采集血样。从患有木胸肌病(n = 33)和未患木胸肌病(n = 33)的肉鸡中选取代表性血样。在实验室中,对血液进行离心,并使用自动生化分析仪进行生化检测。研究结果表明,患有木胸肌病的肉鸡血清肌酸激酶(CK)(P = 0.018)、钾(P = 0.010)和丙氨酸转氨酶(ALT)(P = 0.012)水平升高。总之,血清CK和钾水平升高表明骨骼肌细胞受损。此外,ALT水平升高表明木胸肌病与肝损伤之间可能存在关联。此外,这些研究结果强调了CK的诊断意义,并暗示其作为木胸肌病生物标志物的潜力。