Marghescu Angela-Ștefania, Vlăsceanu Silviu, Preda Mădălina, Țigău Mirela, Dumitrache-Rujinski Ștefan, Leonte Diana Gabriela, Măgheran Elena Doina, Tudor Adrian, Bădărău Ioana Anca, Georgescu Livia, Costache Mariana
Pathology Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Research, Marius Nasta Institute of Pneumophthisiology, 050159 Bucharest, Romania.
Cancers (Basel). 2024 May 16;16(10):1903. doi: 10.3390/cancers16101903.
Pulmonary oncological pathologies are an important public health problem and the association with other pulmonary lesions may pose difficulties in diagnosis and staging or require different treatment options. To address this complexity, we conducted a retrospective observational study at the Marius Nasta Institute of Pneumophthisiology, Bucharest, Romania. Our study focused on patients admitted in 2019 with non-small-cell lung carcinoma and associated pulmonary lesions identified through surgical resection specimens. Among the 314 included patients, multiple pulmonary nodules were observed on macroscopic examination, with 12% (N = 37) exhibiting nonmalignant etiologies upon microscopic examination. These findings underscore the challenge of preoperative staging. Patients with coexisting nonmalignant lesions were similar in age, smoking habits, and professional or environmental exposure by comparison with those who presented only malignant lesions. The presentation of coexisting malignant and nonmalignant lesions may pose difficulties in diagnosing and staging pulmonary cancer.
肺部肿瘤病理学是一个重要的公共卫生问题，与其他肺部病变的关联可能会给诊断和分期带来困难，或者需要不同的治疗方案。为了解决这一复杂性问题，我们在罗马尼亚布加勒斯特的马里乌斯·纳斯塔肺病研究所进行了一项回顾性观察研究。我们的研究聚焦于2019年入院的非小细胞肺癌患者以及通过手术切除标本确定的相关肺部病变。在纳入研究的314例患者中，肉眼检查发现多个肺结节，其中12%（N = 37）在显微镜检查时显示为非恶性病因。这些发现凸显了术前分期的挑战。与仅出现恶性病变的患者相比，伴有非恶性病变的患者在年龄、吸烟习惯以及职业或环境暴露方面相似。同时存在恶性和非恶性病变的情况可能会给肺癌的诊断和分期带来困难。
