Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania.
Microbiology, Parasitology and Virology Discipline, Department of Fundamental Sciences, Faculty of Midwives and Nursing, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Int J Environ Res Public Health. 2023 Jan 10;20(2):1282. doi: 10.3390/ijerph20021282.
Lung cancer and pulmonary tuberculosis are two significant public health problems that continue to take millions of lives each year. They may have similar symptoms and, in some cases, are diagnosed simultaneously or may have a causal relationship. In tuberculosis disease, the chronic inflammation, different produced molecules, genomic changes, and fibrosis are believed to be important factors that may promote carcinogenesis. As a reverse reaction, the development of carcinogenesis and the treatment may induce the reactivation of latent tuberculosis infection. Moreover, the recently used checkpoint inhibitors are a debatable subject since they help treat lung cancer but may lead to the reactivation of pulmonary tuberculosis and checkpoint-induced pneumonitis. Pulmonary rehabilitation is an effective intervention in post-tuberculosis patients and lung cancer patients and should be recommended to improve outcomes in these pathologies.
肺癌和肺结核是两个重大的公共卫生问题，每年仍夺走数百万人的生命。它们可能有相似的症状，在某些情况下，会被同时诊断出，或者可能存在因果关系。在结核病中，慢性炎症、不同产生的分子、基因组改变和纤维化被认为是可能促进癌变的重要因素。相反，癌变的发展和治疗可能会引发潜伏性结核感染的再激活。此外，最近使用的检查点抑制剂是一个有争议的话题，因为它们有助于治疗肺癌，但可能导致肺结核的再激活和检查点诱导性肺炎。肺康复是肺结核和肺癌患者的有效干预措施，应推荐其改善这些疾病的预后。
