Baker J K, McChesney J D, Jorge L
Bull World Health Organ. 1985;63(5):887-91.
A simple method of screening large numbers of urine samples for the presence of primaquine metabolites has been developed using a commercially available diazonium salt reagent and an extraction cartridge. The extraction requires only 1.0 ml of urine and is selective for acidic or neutral primaquine metabolites. With primaquine-dosed rats, primaquine metabolites could be detected 36 hours after administration of the drug. The sensitivity of the method was found to be approximately 400 mug/l.
已开发出一种使用市售重氮盐试剂和萃取柱来筛查大量尿液样本中是否存在伯氨喹代谢物的简单方法。萃取仅需1.0毫升尿液，且对酸性或中性伯氨喹代谢物具有选择性。对于给予伯氨喹的大鼠，在给药后36小时可检测到伯氨喹代谢物。该方法的灵敏度约为400微克/升。
