Kim Dong-Kyu
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, Republic of Korea.
Institute of New Frontier Research, Division of Big Data and Artificial Intelligence, Hallym University College of Medicine, Chuncheon 24253, Republic of Korea.
Cancers (Basel). 2024 May 18;16(10):1930. doi: 10.3390/cancers16101930.
Enhanced screening protocols for cancer detection have increased survival in patients with head and neck cancer (HNC), which highlights the need to address the sequelae of therapy-induced cardiovascular complications. This study was conducted to assess the incidence and risk of acute myocardial infarction (AMI) in patients with HNC who have not undergone radiation or chemotherapy using a comprehensive, population-based cohort dataset. A total of 2976 individuals without cancer and 744 individuals with HNC were matched using the propensity score method. The findings indicated that the occurrence rates of AMI were comparable between the HNC (2.19) and non-cancer groups (2.39). Cox regression analysis did not demonstrate a significant increase in the risk of AMI in patients with HNC (hazard ratio: 0.93, 95% confidence interval: 0.50-1.73). No increased risk of AMI was observed in the HNC group compared to the non-cancer group, regardless of the time since the HNC diagnosis. Subgroup analyses showed no notable differences in the AMI risk between the groups when considering sex, age, comorbidities, and cancer type. This study showed that patients with HNC who have not been treated with radiation or chemotherapy did not exhibit an increased incidence or risk of AMI compared to individuals without cancer.
用于癌症检测的强化筛查方案提高了头颈癌（HNC）患者的生存率，这凸显了应对治疗引起的心血管并发症后遗症的必要性。本研究旨在使用基于人群的综合队列数据集，评估未接受放疗或化疗的HNC患者急性心肌梗死（AMI）的发生率和风险。采用倾向评分法对2976名无癌症个体和744名HNC患者进行匹配。研究结果表明，HNC组（2.19）和非癌症组（2.39）的AMI发生率相当。Cox回归分析未显示HNC患者发生AMI的风险显著增加（风险比：0.93，95%置信区间：0.50-1.73）。与非癌症组相比，无论自HNC诊断以来的时间长短，HNC组均未观察到AMI风险增加。亚组分析显示，在考虑性别、年龄、合并症和癌症类型时，两组之间的AMI风险无显著差异。本研究表明，未接受放疗或化疗的HNC患者与无癌症个体相比，未表现出AMI发生率或风险增加。
