玫瑰他汀合成的最新进展

Recent Advances in the Synthesis of Rosettacin.

作者信息

Tang Xiao, Jiang Yukang, Song Liangliang, Van der Eycken Erik V

机构信息

College of Science, Nanjing Forestry University, Nanjing 210037, China.

Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.

出版信息

Molecules. 2024 May 7;29(10):2176. doi: 10.3390/molecules29102176.

DOI:10.3390/molecules29102176

PMID:38792039

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11124376/

Abstract

Camptothecin and its analogues show important antitumor activity and have been used in clinical studies. However, hydrolysis of lactone in the E ring seriously attenuates the antitumor activity. To change this situation, aromathecin alkaloids are investigated in order to replace camptothecins. Potential antitumor activity has obtained more and more attention from organic and pharmaceutical chemists. As a member of the aromathecin alkaloids, rosettacin has been synthesized via different methods. This review summarizes recent advances in the synthesis of rosettacin.

摘要

喜树碱及其类似物具有重要的抗肿瘤活性，并已用于临床研究。然而，E环内酯的水解严重削弱了其抗肿瘤活性。为改变这种情况，人们对芳香喜树碱类生物碱进行了研究，以取代喜树碱。其潜在的抗肿瘤活性越来越受到有机化学家和药物化学家的关注。作为芳香喜树碱类生物碱的一员，玫瑰树碱已通过不同方法合成。本综述总结了玫瑰树碱合成的最新进展。