基于碳二亚胺的氮杂环合成：从两个经典反应位点到化学键断裂/形成反应
Carbodiimide-based synthesis of N-heterocycles: moving from two classical reactive sites to chemical bond breaking/forming reaction.
作者信息
Wang Yang, Zhang Wen-Xiong, Xi Zhenfeng
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Beijing National Laboratory for Molecular Sciences, MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China.
出版信息
Chem Soc Rev. 2020 Jul 13. doi: 10.1039/c9cs00478e.
Carbodiimides are a unique class of heterocumulene compounds that display distinctive chemical properties. The rich chemistry of carbodiimides has drawn increasing attention from chemists in recent years and has made them exceedingly useful compounds in modern organic chemistry, especially in the synthesis of N-heterocycles. This review has outlined the extensive application of carbodiimides in the synthesis of N-heterocycles from the 1980s to today. A wide range of reactions for the synthesis of various types of N-heterocyclic systems (three-, four-, five-, six-, seven-, larger-membered and fused heterocycles) have been developed on the basis of carbodiimides and their derivatives.
碳二亚胺是一类独特的杂累积烯烃化合物，具有独特的化学性质。近年来，碳二亚胺丰富的化学性质引起了化学家们越来越多的关注，并使其成为现代有机化学中极为有用的化合物，尤其是在N-杂环的合成中。本综述概述了从20世纪80年代至今碳二亚胺在N-杂环合成中的广泛应用。基于碳二亚胺及其衍生物，已经开发出了一系列用于合成各种类型N-杂环体系（三元、四元、五元、六元、七元、更大环和稠合杂环）的反应。
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