Chankvetadze Bezhan, Kartozia Irma, Yamamoto Chiyo, Okamoto Yoshio
Molecular Recognition and Separation Science Laboratory, School of Chemistry, Tbilisi State University, Chavchavadze Ave 1, 380028 Tbilisi, Georgia.
J Pharm Biomed Anal. 2002 Jan 15;27(3-4):467-78. doi: 10.1016/s0731-7085(01)00648-3.
The enantiomers of randomly selected chiral drugs and drug analogs of various structural and pharmacological groups were resolved on four different polysaccharide-type chiral stationary phases (CSP) using pure methanol and acetonitrile as mobile phases. Polysaccharide phenylester type CSP, Chiralcel-OJ although resolving the enantiomers of some chiral drugs was less universal in the combination with methanol and acetonitrile as mobile phases. Among polysaccharide phenylcarabamates amylose tris(3,5-dimethylphenylcarbamate) (Chiralpak-AD) was superior over the corresponding cellulose derivative, cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel-OD). However, another derivative of cellulose, namely, cellulose tris(3,5-dichlorophenylcarbamate) (CDCPC) exhibited higher chiral recognition ability compared to Chiralpak-AD material. This study confirms previous findings about the applicability of polysaccharide type CSPs in so called polar organic mode as well as shows high potential of CDCPC as a practically useful CSP for High performance liquid chromatography (HPLC) enantioseparations.
使用纯甲醇和乙腈作为流动相，在四种不同的多糖型手性固定相（CSP）上拆分了随机选择的各种结构和药理基团的手性药物及其类似物的对映体。多糖苯基酯型CSP，即Chiralcel - OJ，虽然能拆分某些手性药物的对映体，但在与甲醇和乙腈作为流动相的组合中通用性较差。在多糖苯基氨基甲酸酯中，直链淀粉三（3,5 - 二甲基苯基氨基甲酸酯）（Chiralpak - AD）优于相应的纤维素衍生物，即纤维素三（3,5 - 二甲基苯基氨基甲酸酯）（Chiralcel - OD）。然而，纤维素的另一种衍生物，即纤维素三（3,5 - 二氯苯基氨基甲酸酯）（CDCPC），与Chiralpak - AD材料相比，表现出更高的手性识别能力。本研究证实了先前关于多糖型CSP在所谓极性有机模式中的适用性的发现，同时也显示了CDCPC作为高效液相色谱（HPLC）对映体拆分中一种实际有用的CSP的巨大潜力。
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