感染艾滋病毒的成年人对疫苗接种的免疫和临床反应。
Immunological and Clinical Responses to Vaccinations among Adults Living with HIV.
作者信息
Bieńkowski Carlo, Żak Zuzanna, Fijołek Filip, Cholewik Martyna, Stępień Maciej, Skrzat-Klapaczyńska Agata, Kowalska Justyna D
机构信息
Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland.
Department of Adults' Infectious Diseases, Medical University of Warsaw, 01-201 Warsaw, Poland.
出版信息
Life (Basel). 2024 Apr 24;14(5):540. doi: 10.3390/life14050540.
People living with human immunodeficiency virus (HIV) are at higher risk of morbidity and mortality due to vaccine-preventable diseases. At the same time, they are less likely to respond to vaccinations, and might have a higher rate of vaccine adverse event and faster waning of protective effect. International and national guidelines emphasize the importance of vaccinating people living with HIV against respiratory system disease pathogens including seasonal influenza, , and COVID-19, as well as against sexually transmitted infections, i.e., Hepatitis A and B (HAV, HBV) and human papillomavirus (HPV). This narrative review aims to provide a comprehensive examination of the current knowledge regarding the immune and clinical responses elicited by vaccinations in the older adult population living with HIV.
感染人类免疫缺陷病毒（HIV）的人因疫苗可预防疾病而面临更高的发病和死亡风险。与此同时，他们对疫苗接种的反应较小，可能发生疫苗不良事件的几率更高，且保护作用的减弱速度更快。国际和国家指南强调，为感染HIV的人接种针对包括季节性流感、[此处原文缺失部分内容]和2019冠状病毒病（COVID-19）在内的呼吸系统疾病病原体的疫苗，以及针对性传播感染，即甲型和乙型肝炎（HAV、HBV）和人乳头瘤病毒（HPV）的疫苗的重要性。本叙述性综述旨在全面审视有关HIV感染老年人群接种疫苗后引发的免疫和临床反应的现有知识。
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