Bieńkowski Carlo, Kowalska Justyna D, Paciorek Marcin, Wasilewski Piotr, Uliczny Paweł, Garbacz-Łagożna Ewelina, Pihowicz Andrzej, Mrozińska Monika, Dyda Tomasz, Makowiecki Michał, Puła Joanna, Horban Andrzej
Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland.
Department of Adults' Infectious Diseases, Medical University of Warsaw, 01-201 Warsaw, Poland.
J Clin Med. 2022 Dec 13;11(24):7386. doi: 10.3390/jcm11247386.
Background: The first case of coronavirus disease 2019 (COVID-19) in Poland was reported on 4 March 2020. We aim to compare the clinical course and outcomes of patients hospitalized in the Hospital for Infectious Diseases in Warsaw due to COVID-19 during three pandemic waves. Materials and methods: The medical data were collected for all patients diagnosed with COVID-19 hospitalized in our hospital from 6 March 2020 till 30 November 2021. COVID-19 diagnosis was confirmed by nasopharyngeal swabs using real-time polymerase chain reaction assay (RT-PCR) or SARS-CoV-2 antigen test. COVID-19 waves were defined based on the number and dynamics of cases. Results: Altogether, 2138 patient medical records were analyzed. The majority of the cohort was male (1235/2138, 57.8%), and the median age was 65 years [IQR: 50−74 years]. Patients hospitalized during the third wave had lower oxygen saturation on admission (p < 0.001) and were more likely to receive oxygen supplementation (p < 0.001). Serious complications, including pneumothorax (p < 0.001) and thromboembolic complications (p < 0.001), intensive care unit admission (p = 0.034), and death (p = 0.003), occurred more often in patients of the third wave. Conclusions: During the third wave, patients in our cohort experienced a more severe course of the disease and poorer outcomes.
2020年3月4日，波兰报告了首例2019冠状病毒病（COVID-19）病例。我们旨在比较三波疫情期间因COVID-19在华沙传染病医院住院患者的临床病程和结局。材料与方法：收集了2020年3月6日至2021年11月30日在我院确诊为COVID-19的所有住院患者的医疗数据。采用实时聚合酶链反应检测（RT-PCR）或SARS-CoV-2抗原检测通过鼻咽拭子确诊COVID-19。根据病例数量和动态定义COVID-19疫情波次。结果：共分析了2138份患者病历。队列中的大多数患者为男性（1235/2138，57.8%），中位年龄为65岁[四分位间距：50 - 74岁]。第三波疫情期间住院的患者入院时氧饱和度较低（p < 0.001），且更有可能接受氧疗（p < 0.001）。严重并发症，包括气胸（p < 0.001）和血栓栓塞并发症（p < 0.001）、入住重症监护病房（p = 0.034）和死亡（p = 0.003），在第三波疫情期间的患者中更为常见。结论：在第三波疫情期间，我们队列中的患者经历了更严重的病程和更差的结局。
