自催化选择作为生命起源的驱动力

Autocatalytic Selection as a Driver for the Origin of Life.

作者信息

Williamson Mike P

机构信息

School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK.

出版信息

Life (Basel). 2024 May 6;14(5):590. doi: 10.3390/life14050590.

Abstract

Darwin's theory of evolution by natural selection was revolutionary because it provided a mechanism by which variation could be selected. This mechanism can only operate on living systems and thus cannot be applied to the origin of life. Here, we propose a viable alternative mechanism for prebiotic systems: autocatalytic selection, in which molecules catalyze reactions and processes that lead to increases in their concentration. Crucially, this provides a driver for increases in concentrations of molecules to a level that permits prebiotic metabolism. We show how this can produce high levels of amino acids, sugar phosphates, nucleotides and lipids and then lead on to polymers. Our outline is supported by a set of guidelines to support the identification of the most likely prebiotic routes. Most of the steps in this pathway are already supported by experimental results. These proposals generate a coherent and viable set of pathways that run from established Hadean geochemistry to the beginning of life.

摘要

达尔文的自然选择进化论具有革命性,因为它提供了一种能够对变异进行选择的机制。这种机制只能作用于生命系统,因此无法应用于生命起源。在此,我们为前生物系统提出一种可行的替代机制:自催化选择,即分子催化导致其浓度增加的反应和过程。至关重要的是,这为分子浓度增加到允许前生物代谢的水平提供了驱动力。我们展示了这如何能够产生高水平的氨基酸、糖磷酸、核苷酸和脂质,进而形成聚合物。我们的概述得到了一套指导方针的支持,以帮助识别最有可能的前生物途径。该途径中的大多数步骤已经得到实验结果的支持。这些提议产生了一组连贯且可行的途径,从已确定的冥古宙地球化学一直延伸到生命的开端。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f3/11122578/6eb69c424229/life-14-00590-g001.jpg

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