Mielens Z E, Connolly K, Stecher V J
J Rheumatol. 1985 Dec;12(6):1083-7.
Intrapleural injections of carrageenan into rats resulted in peak increases in intrapleural inflammatory cell counts (90% mononuclear cells) and fibronectin content at 3 days after the injections. Administration of disease modifying antirheumatic drugs (DMARD) prevented the increases in both fibronectin levels and intrapleural cell counts, whereas nonsteroidal antiinflammatory drugs, in general, potentiated the increases. Inhibition of fibronectin production by DMARD in carrageenan induced pleurisy in rats may be related to the antirheumatic activity of this class of drugs.
向大鼠胸膜腔内注射角叉菜胶会导致注射后3天胸膜腔内炎性细胞计数（90%为单核细胞）和纤连蛋白含量达到峰值增加。给予改善病情抗风湿药（DMARD）可防止纤连蛋白水平和胸膜腔内细胞计数的增加，而一般来说，非甾体抗炎药会增强这种增加。DMARD对角叉菜胶诱导的大鼠胸膜炎中纤连蛋白产生的抑制作用可能与这类药物的抗风湿活性有关。
