Cammayo-Fletcher Paula Leona T, Flores Rochelle A, Nguyen Binh T, Altanzul Bujinlkham, Fernandez-Colorado Cherry P, Kim Woo H, Devi Rajkumari Mandakini, Kim Suk, Min Wongi
College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
Department of Veterinary Paraclinical Sciences, College of Veterinary Medicine, University of the Philippines Los Baños, Los Baños 4031, Philippines.
Microorganisms. 2024 May 12;12(5):973. doi: 10.3390/microorganisms12050973.
(RA) is an economically important pathogen in the duck industry worldwide that causes high mortality and morbidity in infected birds. We previously found that upregulated IL-17A expression in ducks infected with RA participates in the pathogenesis of the disease, but this mechanism is not linked to IL-23, which primarily promotes Th17 cell differentiation and proliferation. RNA sequencing analysis was used in this study to investigate other mechanisms of IL-17A upregulation in RA infection. A possible interaction of IL-26 and IL-17 was discovered, highlighting the potential of IL-26 as a novel upstream cytokine that can regulate IL-17A during RA infection. Additionally, this process identified several important pathways and genes related to the complex networks and potential regulation of the host immune response in RA-infected ducks. Collectively, these findings not only serve as a roadmap for our understanding of RA infection and the development of new immunotherapeutic approaches for this disease, but they also provide an opportunity to understand the immune system of ducks.
禽致病性大肠杆菌（RA）是全球鸭产业中一种具有重要经济影响的病原体，可导致感染禽类的高死亡率和高发病率。我们之前发现，感染RA的鸭中白细胞介素-17A（IL-17A）表达上调参与了该病的发病机制，但这种机制与主要促进Th17细胞分化和增殖的白细胞介素-23（IL-23）无关。本研究采用RNA测序分析来探究RA感染中IL-17A上调的其他机制。发现了IL-26与IL-17之间可能存在的相互作用，凸显了IL-26作为一种新型上游细胞因子在RA感染期间调节IL-17A的潜力。此外，该过程确定了与RA感染鸭宿主免疫反应的复杂网络和潜在调节相关的几个重要途径和基因。总体而言，这些发现不仅为我们理解RA感染及开发针对该疾病的新免疫治疗方法提供了路线图，还为了解鸭的免疫系统提供了契机。
