Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928, Street 2, Xiasha Higher Education Zone, Hangzhou, 310018, Zhejiang, China.
Department of Oncology, The 903rd Hospital of PLA, Hangzhou, 310013, Zhejiang, China.
Mil Med Res. 2021 Sep 9;8(1):48. doi: 10.1186/s40779-021-00343-2.
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
由于抗生素耐药菌的快速进化，细菌感染的管理正成为一个主要的临床挑战。抗菌肽（AMPs）作为克服抗生素耐药性的优秀候选物，来源于合成和天然来源，表现出广谱抗菌活性，具有高度特异性和低毒性。这些肽通过采用复杂的作用机制，具有独特的结构和功能。本综述全面概述了 AMPs 的起源、结构特征、作用机制、生物学活性到临床应用。最后，我们讨论了优化和开发基于 AMP 的治疗方法的策略，作为潜在的抗菌和抗癌治疗方法。
