Faculty of Medicine, Titu Maiorescu University, 040441 Bucharest, Romania.
Medical Oncology Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Medicina (Kaunas). 2024 Apr 24;60(5):696. doi: 10.3390/medicina60050696.
Metastatic colorectal cancer requires a multidisciplinary and individualized approach. Herein, we reported the case of a young woman diagnosed with metastatic rectal cancer who received an individualized multimodal treatment strategy that resulted in a remarkable survival. There were several particular aspects of this case, such as the early onset of the disease, the successful use of conversion therapy, the application of liquid biopsy to guide treatment, and the specific nature of the bone metastasis. To offer more insights for navigating such challenges in patients with metastatic colorectal cancer, we have conducted a literature review to find more data related to the particularities of this case. The incidence of early onset colorectal cancer is on the rise. Data suggests that it differs from older-onset colorectal cancer in terms of its pathological, epidemiological, anatomical, metabolic, and biological characteristics. Conversion therapy and surgical intervention provide an opportunity for cure and improve outcomes in metastatic colorectal cancer. It is important to approach each case individually, as every patient with limited liver disease should be considered as a candidate for secondary resection. Moreover, liquid biopsy has an important role in the individualized management of metastatic colorectal cancer patients, as it offers additional information for treatment decisions.
转移性结直肠癌需要多学科和个体化的治疗方法。在此，我们报告了一例年轻女性患有转移性直肠癌症的病例，她接受了个体化的多模式治疗策略，取得了显著的生存效果。该病例有几个特殊方面，例如疾病的早期发病、转化治疗的成功应用、液体活检在指导治疗中的应用以及骨转移的特异性。为了在转移性结直肠癌患者中遇到这些挑战时提供更多的见解，我们进行了文献复习，以找到更多与该病例特殊性相关的数据。早发性结直肠癌的发病率呈上升趋势。数据表明，其在病理、流行病学、解剖、代谢和生物学特征方面与老年发病的结直肠癌不同。转化治疗和手术干预为转移性结直肠癌患者提供了治愈的机会，并改善了预后。对每个病例进行个体化治疗非常重要，因为每个有限肝脏疾病的患者都应被视为二次切除的候选者。此外，液体活检在转移性结直肠癌患者的个体化管理中具有重要作用，因为它为治疗决策提供了额外的信息。
