Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02477, Republic of Korea.
Department of Physical Medicine and Rehabilitation, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Medicina (Kaunas). 2024 May 1;60(5):754. doi: 10.3390/medicina60050754.
: Sarcopenic obesity, a clinical condition coexisting with obesity and sarcopenia, is associated with a high risk of functional impairment, reduced quality of life, and increased mortality. A decline in age-related free testosterone (FT) levels has been reported to be associated with decreased muscle mass and muscle strength and increased fat mass. However, the association between low FT levels and risk of sarcopenic obesity has not been well studied. This study aimed to investigate the direct association between low FT levels and sarcopenic obesity. : This cross-sectional study used data of 982 community-dwelling men aged 70-84 years from the Korean Frailty and Aging Cohort Study. Sarcopenia was defined according to the criteria of the Asian Group for Sarcopenia (AWGS) 2019. Obesity was defined as a body fat mass ≥28.3%. Participants who met both sarcopenia and obesity criteria were defined as having sarcopenic obesity. Low FT levels were defined as FT levels <17.35 pmol/L according to the Endocrine Society Clinical Practice Guidelines. : The prevalence of sarcopenia, obesity, and sarcopenic obesity was significantly higher in the low-FT group than in the normal-FT group. Low FT levels were significantly associated with a higher risk of obesity (odds ratio [OR], 2.09, 95% confidence interval [CI], 1.11-3.92), sarcopenia (2.57, 95% CI 1.08-6.10), and sarcopenic obesity (3.66, 95% CI 1.58-8.47) compared with the healthy control group. The risk of low appendicular skeletal muscle mass index (ASMI) (1.78, 95% CI 1.04-3.02) and high fat mass (1.92, 95% CI 1.12-3.31) was significantly higher in the low-FT group than in the normal-FT group. : This study showed that low FT levels were associated with a higher risk of sarcopenic obesity. Low FT levels were mainly related to body composition parameters such as low ASMI and high fat mass.
: 肌少症性肥胖是一种同时存在肥胖和肌少症的临床病症，与功能障碍、生活质量下降和死亡率增加的风险较高有关。据报道，与年龄相关的游离睾酮（FT）水平下降与肌肉质量和肌肉力量下降以及脂肪质量增加有关。然而，低 FT 水平与肌少症性肥胖风险之间的关联尚未得到充分研究。本研究旨在探讨低 FT 水平与肌少症性肥胖之间的直接关联。 : 这项横断面研究使用了来自韩国虚弱和衰老队列研究的 982 名 70-84 岁的社区居住男性的数据。肌少症根据亚洲肌少症工作组（AWGS）2019 年的标准定义。肥胖定义为体脂肪质量≥28.3%。符合肌少症和肥胖标准的参与者被定义为患有肌少症性肥胖。根据内分泌学会临床实践指南，低 FT 水平定义为 FT 水平<17.35 pmol/L。 : 低 FT 组的肌少症、肥胖和肌少症性肥胖的患病率明显高于正常 FT 组。与健康对照组相比，低 FT 水平与肥胖（比值比[OR]，2.09，95%置信区间[CI]，1.11-3.92）、肌少症（2.57，95%CI 1.08-6.10）和肌少症性肥胖（3.66，95%CI 1.58-8.47）的风险显著增加。与正常 FT 组相比，低 FT 组低四肢骨骼肌质量指数（ASMI）（1.78，95%CI 1.04-3.02）和高脂肪质量（1.92，95%CI 1.12-3.31）的风险显著增加。 : 本研究表明，低 FT 水平与肌少症性肥胖的风险增加有关。低 FT 水平主要与身体成分参数有关，如低 ASMI 和高脂肪质量。
