Diago-Galmés Angela, Guillamón-Escudero Carlos, Tenías-Burillo Jose M, Soriano Jose M, Fernández-Garrido Julio
Hospital Universitario de La Plana, 12540 Villareal, Spain.
Hospital General Universitari de Castelló, 12004 Castellón, Spain.
Biology (Basel). 2021 Jan 27;10(2):93. doi: 10.3390/biology10020093.
Nowadays, the appearance of sarcopenia (S) or sarcopenic obesity (SO) is related to aging. According to the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP), the feasibility of using salivary cortisol and testosterone levels was analyzed as diagnostic biomarkers of S or SO. One hundred and ninety non-institutionalized people aged ≥65 years were studied, independent of the activities of daily living (ADLs) (Barthel > 60), and sociodemographic variables were determined together with criteria for the diagnosis of S and SO including grip force, lower body strength, appendicular skeletal muscle mass, physical performance, total body fat percentage, body mass index (BMI), waist circumference, and triceps skinfold, together with the levels of salivary cortisol and testosterone. Our results reflected that women presented a higher prevalence of S and SO (21.2% and 30.2%, respectively). A significant difference was observed between salivary testosterone levels and the age of the participants with differences by sex. Testosterone values in men with S and SO were significantly lower ( = 0.043 and = 0.048, respectively), which suggests a potential use of the biomarker for diagnostic purposes. No significant differences were shown with cortisol values.
如今，肌肉减少症（S）或肌肉减少性肥胖（SO）的出现与衰老有关。根据欧洲老年人肌肉减少症工作组（EWGSOP）的标准，分析了唾液皮质醇和睾酮水平作为S或SO诊断生物标志物的可行性。对190名年龄≥65岁的非机构化人员进行了研究，这些人员独立于日常生活活动（ADL）（巴氏指数>60），并确定了社会人口统计学变量以及S和SO的诊断标准，包括握力、下肢力量、四肢骨骼肌质量、身体表现、体脂百分比、体重指数（BMI）、腰围和肱三头肌皮褶厚度，以及唾液皮质醇和睾酮水平。我们的结果表明，女性中S和SO的患病率更高（分别为21.2%和30.2%）。观察到唾液睾酮水平与参与者年龄之间存在显著差异，且存在性别差异。患有S和SO的男性的睾酮值显著较低（分别为=0.043和=0.048），这表明该生物标志物在诊断方面具有潜在用途。皮质醇值未显示出显著差异。
