Li Fei, Dang Wenrui, Du Yunjie, Xu Xiaonan, He Pu, Zhou Yuhe, Zhu Bingdong
State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Center for Tuberculosis Research, Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
College of Veterinary Medicine, Lanzhou University, Lanzhou 730000, China.
Vaccines (Basel). 2024 Apr 30;12(5):483. doi: 10.3390/vaccines12050483.
Tuberculosis (TB) remains a major infectious disease partly due to the lack of an effective vaccine. Therefore, developing new and more effective TB vaccines is crucial for controlling TB. () usually parasitizes in macrophages; therefore, cell-mediated immunity plays an important role. The maintenance of memory T cells following infection or vaccination is a hallmark of immune protection. This review analyzes the development of memory T cells during infection and vaccine immunization, especially on immune memory induced by BCG and subunit vaccines. Furthermore, the factors affecting the development of memory T cells are discussed in detail. The understanding of the development of memory T cells should contribute to designing more effective TB vaccines and optimizing vaccination strategies.
结核病（TB）仍然是一种主要的传染病，部分原因是缺乏有效的疫苗。因此，开发新的、更有效的结核病疫苗对于控制结核病至关重要。（结核杆菌）通常寄生于巨噬细胞中；因此，细胞介导的免疫起着重要作用。感染或接种疫苗后记忆T细胞的维持是免疫保护的一个标志。本综述分析了结核杆菌感染和疫苗免疫过程中记忆T细胞的发育情况，特别是卡介苗和亚单位疫苗诱导的免疫记忆。此外，还详细讨论了影响记忆T细胞发育的因素。对记忆T细胞发育的理解应有助于设计更有效的结核病疫苗和优化疫苗接种策略。
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