School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian 116024, China.
Rehabilitation Medicine Department, The Second Hospital of Dalian Medical University, Dalian 116033, China.
Sensors (Basel). 2024 May 11;24(10):3051. doi: 10.3390/s24103051.
(1) Background: This study evaluates the effectiveness of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) in improving gait in post-stroke hemiplegic patients, using wearable sensor technology for objective gait analysis. (2) Methods: A total of 72 stroke patients were randomized into control, sham stimulation, and LF-rTMS groups, with all receiving standard medical treatment. The LF-rTMS group underwent stimulation on the unaffected hemisphere for 6 weeks. Key metrics including the Fugl-Meyer Assessment Lower Extremity (FMA-LE), Berg Balance Scale (BBS), Modified Barthel Index (MBI), and gait parameters were measured before and after treatment. (3) Results: The LF-rTMS group showed significant improvements in the FMA-LE, BBS, MBI, and various gait parameters compared to the control and sham groups ( < 0.05). Specifically, the FMA-LE scores improved by an average of 5 points (from 15 ± 3 to 20 ± 2), the BBS scores increased by 8 points (from 35 ± 5 to 43 ± 4), the MBI scores rose by 10 points (from 50 ± 8 to 60 ± 7), and notable enhancements in gait parameters were observed: the gait cycle time was reduced from 2.05 ± 0.51 s to 1.02 ± 0.11 s, the stride length increased from 0.56 ± 0.04 m to 0.97 ± 0.08 m, and the walking speed improved from 35.95 ± 7.14 cm/s to 75.03 ± 11.36 cm/s (all < 0.001). No adverse events were reported. The control and sham groups exhibited improvements but were not as significant. (4) Conclusions: LF-rTMS on the unaffected hemisphere significantly enhances lower-limb function, balance, and daily living activities in subacute stroke patients, with the gait parameters showing a notable improvement. Wearable sensor technology proves effective in providing detailed, objective gait analysis, offering valuable insights for clinical applications in stroke rehabilitation.
(1)背景:本研究旨在评估低频重复经颅磁刺激(LF-rTMS)结合可穿戴传感器技术进行客观步态分析,对改善脑卒中偏瘫患者步态的有效性。(2)方法:将 72 例脑卒中患者随机分为对照组、假刺激组和 LF-rTMS 组,均接受标准药物治疗。LF-rTMS 组接受 6 周非优势半球刺激。治疗前后分别采用 Fugl-Meyer 评估下肢部分(FMA-LE)、Berg 平衡量表(BBS)、改良巴氏指数(MBI)和步态参数进行评估。(3)结果:与对照组和假刺激组相比,LF-rTMS 组的 FMA-LE、BBS、MBI 和各种步态参数均有显著改善( < 0.05)。具体而言,FMA-LE 评分平均提高 5 分(从 15 ± 3 分提高至 20 ± 2 分),BBS 评分提高 8 分(从 35 ± 5 分提高至 43 ± 4 分),MBI 评分提高 10 分(从 50 ± 8 分提高至 60 ± 7 分),并且观察到显著的步态参数改善:步态周期时间从 2.05 ± 0.51 s 缩短至 1.02 ± 0.11 s,步长从 0.56 ± 0.04 m 增加至 0.97 ± 0.08 m,步行速度从 35.95 ± 7.14 cm/s 提高至 75.03 ± 11.36 cm/s(均 < 0.001)。未报告不良事件。对照组和假刺激组也有改善,但不如 LF-rTMS 组显著。(4)结论:非优势半球的 LF-rTMS 可显著改善亚急性期脑卒中患者的下肢功能、平衡和日常生活活动能力,并且步态参数有显著改善。可穿戴传感器技术可有效提供详细的客观步态分析,为脑卒中康复的临床应用提供有价值的信息。