Fang Weixiang, Yu Kailing, Zhang Songhan, Jiang Lai, Zheng Hongyue, Huang Qiaoling, Li Fanzhu
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Libraries of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Pharmaceutics. 2024 May 8;16(5):632. doi: 10.3390/pharmaceutics16050632.
A nanoparticle's shape is a critical determinant of its biological interactions and therapeutic effectiveness. This study investigates the influence of shape on the performance of mesoporous silica nanoparticles (MSNs) in anticancer therapy. MSNs with spherical, rod-like, and hexagonal-plate-like shapes were synthesized, with particle sizes of around 240 nm, and their other surface properties were characterized. The drug loading capacities of the three shapes were controlled to be 47.46%, 49.41%, and 46.65%, respectively. The effects of shape on the release behaviors, cellular uptake mechanisms, and pharmacological behaviors of MSNs were systematically investigated. Through a series of in vitro studies using 4T1 cells and in vivo evaluations in 4T1 tumor-bearing mice, the release kinetics, cellular behaviors, pharmacological effects, circulation profiles, and therapeutic efficacy of MSNs were comprehensively assessed. Notably, hexagonal-plate-shaped MSNs loaded with PTX exhibited a prolonged circulation time ( = 13.59 ± 0.96 h), which was approximately 1.3 times that of spherical MSNs ( = 10.16 ± 0.38 h) and 1.5 times that of rod-shaped MSNs ( = 8.76 ± 1.37 h). This research underscores the significance of nanoparticles' shapes in dictating their biological interactions and therapeutic outcomes, providing valuable insights for the rational design of targeted drug delivery systems in cancer therapy.
纳米颗粒的形状是其生物相互作用和治疗效果的关键决定因素。本研究调查了形状对介孔二氧化硅纳米颗粒（MSNs）抗癌治疗性能的影响。合成了球形、棒状和六方板状的MSNs，粒径约为240 nm，并对其其他表面性质进行了表征。三种形状的载药能力分别控制为47.46%、49.41%和46.65%。系统研究了形状对MSNs释放行为、细胞摄取机制和药理行为的影响。通过一系列使用4T1细胞的体外研究和对4T1荷瘤小鼠的体内评估，全面评估了MSNs的释放动力学、细胞行为、药理作用、循环特征和治疗效果。值得注意的是，负载PTX的六方板状MSNs的循环时间延长（ = 13.59 ± 0.96 h），约为球形MSNs（ = 10.16 ± 0.38 h）的1.3倍，棒状MSNs（ = 8.76 ± 1.37 h）的1.5倍。本研究强调了纳米颗粒形状在决定其生物相互作用和治疗结果方面的重要性，为癌症治疗中靶向药物递送系统的合理设计提供了有价值的见解。
