Fan Youfang, Sun Chao, Yan Kan, Li Pengcheng, Hein Ingo, Gilroy Eleanor M, Kear Philip, Bi Zhenzhen, Yao Panfeng, Liu Zhen, Liu Yuhui, Bai Jiangping
State Key Laboratory of Aridland Crop Science, College of Agronomy, Gansu Agricultural University, Lanzhou 730070, China.
School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
Plants (Basel). 2024 May 17;13(10):1400. doi: 10.3390/plants13101400.
As global arid conditions worsen and groundwater resources diminish, drought stress has emerged as a critical impediment to plant growth and development globally, notably causing declines in crop yields and even the extinction of certain cultivated species. Numerous studies on drought resistance have demonstrated that DNA methylation dynamically interacts with plant responses to drought stress by modulating gene expression and developmental processes. However, the precise mechanisms underlying these interactions remain elusive. This article consolidates the latest research on the role of DNA methylation in plant responses to drought stress across various species, focusing on methods of methylation detection, mechanisms of methylation pattern alteration (including DNA de novo methylation, DNA maintenance methylation, and DNA demethylation), and overall responses to drought conditions. While many studies have observed significant shifts in genome-wide or gene promoter methylation levels in drought-stressed plants, the identification of specific genes and pathways involved remains limited. This review aims to furnish a reference for detailed research into plant responses to drought stress through epigenetic approaches, striving to identify drought resistance genes regulated by DNA methylation, specific signaling pathways, and their molecular mechanisms of action.
随着全球干旱状况恶化和地下水资源减少，干旱胁迫已成为全球植物生长和发育的关键障碍，尤其导致作物产量下降，甚至某些栽培物种灭绝。众多关于抗旱性的研究表明，DNA甲基化通过调节基因表达和发育过程，与植物对干旱胁迫的反应动态相互作用。然而，这些相互作用背后的确切机制仍然难以捉摸。本文汇总了关于DNA甲基化在不同物种植物对干旱胁迫反应中作用的最新研究，重点关注甲基化检测方法、甲基化模式改变机制（包括DNA从头甲基化、DNA维持甲基化和DNA去甲基化）以及对干旱条件的整体反应。虽然许多研究观察到干旱胁迫植物中全基因组或基因启动子甲基化水平有显著变化，但涉及的特定基因和途径的鉴定仍然有限。本综述旨在为通过表观遗传方法深入研究植物对干旱胁迫的反应提供参考，努力鉴定受DNA甲基化调控的抗旱基因、特定信号通路及其分子作用机制。
