Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei 230032, China.
Molecules. 2020 Dec 28;26(1):92. doi: 10.3390/molecules26010092.
There are abundant sources of anticancer drugs in nature that have a broad prospect in anticancer drug discovery. Natural compounds, with biological activities extracted from plants and marine and microbial metabolites, have significant antitumor effects, but their mechanisms are various. In addition to providing energy to cells, mitochondria are involved in processes, such as cell differentiation, cell signaling, and cell apoptosis, and they have the ability to regulate cell growth and cell cycle. Summing up recent data on how natural products regulate mitochondria is valuable for the development of anticancer drugs. This review focuses on natural products that have shown antitumor effects via regulating mitochondria. The search was done in PubMed, Web of Science, and Google Scholar databases, over a 5-year period, between 2015 and 2020, with a keyword search that focused on natural products, natural compounds, phytomedicine, Chinese medicine, antitumor, and mitochondria. Many natural products have been studied to have antitumor effects on different cells and can be further processed into useful drugs to treat cancer. In the process of searching for valuable new drugs, natural products such as terpenoids, flavonoids, saponins, alkaloids, coumarins, and quinones cover the broad space.
自然界中有丰富的抗癌药物资源，在抗癌药物发现方面具有广阔的前景。从植物、海洋和微生物代谢产物中提取具有生物活性的天然化合物，具有显著的抗肿瘤作用，但作用机制各异。线粒体除了为细胞提供能量外，还参与细胞分化、细胞信号转导和细胞凋亡等过程，具有调节细胞生长和细胞周期的能力。总结近年来关于天然产物如何通过调节线粒体发挥抗癌作用的研究数据，对于开发抗癌药物具有重要价值。本综述重点介绍了通过调节线粒体发挥抗肿瘤作用的天然产物。在 2015 年至 2020 年的 5 年时间内，在 PubMed、Web of Science 和 Google Scholar 数据库中，以天然产物、天然化合物、植物药、中药、抗肿瘤和线粒体为关键词进行了检索。许多天然产物已被研究用于对不同细胞的抗肿瘤作用，并可进一步加工成有用的药物来治疗癌症。在寻找有价值的新药的过程中，萜类、黄酮类、皂苷类、生物碱类、香豆素类和醌类等天然产物涵盖了广泛的领域。
