Mir M Amin, Banik Bimal Krishna
Department of Chemistry, Prince Mohammad Bin Fahd University, AL Khobar, Saudi Arabia.
Curr Top Med Chem. 2025;25(5):533-553. doi: 10.2174/0115680266314693240914070250.
Cancer continues to be a major global health challenge, driving the need for the discovery of novel therapeutic agents. Among these, heterocyclic phytochemicals have gained significant attention for their potential as anticancer agents. This review offers a detailed analysis of various classes of heterocyclic compounds with proven anticancer properties, shedding light on their mechanisms of action. The study draws from a diverse array of natural product sources, detailing the chemical structures and bioactivities of these compounds. Key heterocyclic classes such as alkaloids, flavonoids, coumarins, and terpenoids are emphasized due to their potent anticancer effects. Heterocyclic phytochemicals exhibit diverse anticancer mechanisms, including the modulation of cellular pathways like apoptosis, angiogenesis, and cell cycle progression. The combination of heterocyclic phytochemicals with conventional cancer therapies has shown promising synergistic effects, enhanced treatment efficacy and reducing side effects. The review systematically evaluates both preclinical and clinical studies, revealing the efficacy, safety profiles, and pharmacokinetics of selected heterocyclic compounds. The promising outcomes highlighted in this review underscore the critical need for ongoing research to fully realize the therapeutic potential of heterocyclic phytochemicals in cancer treatment.
癌症仍然是一项重大的全球健康挑战，这推动了对新型治疗药物的探索需求。其中，杂环植物化学物质因其作为抗癌药物的潜力而备受关注。本综述对各类已证实具有抗癌特性的杂环化合物进行了详细分析，阐明了它们的作用机制。该研究取材于各种各样的天然产物来源，详述了这些化合物的化学结构和生物活性。由于其强大的抗癌作用，诸如生物碱、黄酮类化合物、香豆素和萜类化合物等关键杂环类别受到了重点关注。杂环植物化学物质展现出多样的抗癌机制，包括对细胞凋亡、血管生成和细胞周期进程等细胞途径的调节。杂环植物化学物质与传统癌症疗法的联合使用已显示出有前景的协同效应，提高了治疗效果并减少了副作用。本综述系统地评估了临床前和临床研究，揭示了所选杂环化合物的疗效、安全性概况和药代动力学。本综述中突出的有前景的结果强调了持续研究的迫切需求，以便充分实现杂环植物化学物质在癌症治疗中的治疗潜力。
