University of Central Florida College of Medicine, Orlando, FL, USA.
Florida State University College of Medicine, Tallahassee, FL, USA.
Arch Dermatol Res. 2024 May 25;316(6):238. doi: 10.1007/s00403-024-02958-6.
Pyoderma gangrenosum (PG) is a rare inflammatory dermatologic condition with neutrophilic infiltration of the skin that causes pustules and ulcerations. Janus kinase (JAK) inhibitors are immunomodulating agents that have been recently described in the literature as an effective treatment for PG. We describe a patient with PG on the lower extremities successfully treated with baricitinib. We also conducted a narrative review of the literature of PG patients treated with JAK inhibitors who were refractory to other treatments.
坏疽性脓皮病（PG）是一种罕见的皮肤炎症性疾病，其特征为皮肤中性粒细胞浸润导致脓疱和溃疡。Janus 激酶（JAK）抑制剂是一种免疫调节剂，最近的文献报道称其对 PG 有效。我们报告了 1 例下肢 PG 患者，使用巴瑞替尼成功治疗。我们还对其他治疗方法无效的 PG 患者使用 JAK 抑制剂治疗的文献进行了叙述性综述。
