Hanna Gregory L, Liu Yanni, Rentschler Lauren G, Hanna Barbara S, Arnold Paul D, Gehring William J
Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109-5766, USA.
Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Child Psychiatry Hum Dev. 2024 May 25. doi: 10.1007/s10578-024-01711-4.
The error-related negativity (ERN) and error positivity (Pe) are components of the event-related potential following an error that are potential mechanistic biomarkers of obsessive-compulsive disorder (OCD). The study examined the ERN, Pe, flanker task accuracy, and clinical measures in 105 OCD cases and 105 matched healthy controls (HC) ages 8-18 years. Higher flanker task accuracy in all participants was associated with an increased ERN amplitude and increased difference between Pe and correct positivity amplitudes (ΔPe). Compared to HC, OCD cases had an increased ERN but decreased ΔPe and flanker task accuracy. Those differences were also significant in tic-related and non-tic-related OCD cases compared to HC. A lower ΔPe was associated in cases with an earlier age at OCD symptom onset. The results support the hypothesis that OCD involves defects in an error monitoring system and suggest a reduced ΔPe may compromise error signaling and cause uncertainty about the correctness of a response.
错误相关负波（ERN）和错误正波（Pe）是错误发生后事件相关电位的组成部分，是强迫症（OCD）潜在的机制性生物标志物。该研究检测了105例8至18岁的强迫症患者和105名匹配的健康对照（HC）的ERN、Pe、侧翼任务准确性和临床指标。所有参与者更高的侧翼任务准确性与ERN波幅增加以及Pe与正确正波幅之间的差异增加（ΔPe）相关。与健康对照相比，强迫症患者的ERN增加，但ΔPe和侧翼任务准确性降低。与健康对照相比，这些差异在与抽动相关和与抽动无关的强迫症病例中也很显著。较低的ΔPe与强迫症症状发作年龄较早的病例相关。结果支持了强迫症涉及错误监测系统缺陷的假设，并表明较低的ΔPe可能会损害错误信号传递，并导致对反应正确性的不确定性。
