Hanna Gregory, Liu Yanni, Rentschler Lauren, Hanna Barbara, Arnold Paul, Gehring William
University of Michigan-Ann Arbor.
University of Calgary.
Res Sq. 2024 Feb 13:rs.3.rs-3943784. doi: 10.21203/rs.3.rs-3943784/v1.
The error-related negativity (ERN) and error positivity (Pe) are components of the event-related potential following an error that are potential mechanistic biomarkers of obsessive-compulsive disorder (OCD). The study examined the ERN, Pe, flanker task accuracy, and clinical measures in 105 OCD cases and 105 matched healthy controls (HC), ages 8 to 18 years, with 21 cases having a tic disorder history. Higher flanker task accuracy in all participants was associated with an increased ERN amplitude and increased difference between Pe and correct positivity amplitudes (ΔPe). Compared to HC, OCD cases had an increased ERN but flanker task accuracy and ΔPe. Those differences were also significant in tic-related and non-tic-related OCD cases compared to HC. A lower ΔPe was associated in OCD cases with an earlier age at OCD symptom onset. The results support the hypothesis that OCD involves defects in an error monitoring system and suggest a reduced ΔPe may compromise error signaling and cause uncertainty about the correctness of a response.
错误相关负波（ERN）和错误正波（Pe）是错误发生后事件相关电位的组成部分，是强迫症（OCD）潜在的机制性生物标志物。该研究对105例强迫症患者和105名匹配的健康对照（HC）进行了ERN、Pe、侧翼任务准确性和临床指标的检测，这些患者和对照年龄在8至18岁之间，其中21例有抽动障碍病史。所有参与者更高的侧翼任务准确性与ERN波幅增加以及Pe与正确正波幅之间的差异增加（ΔPe）相关。与健康对照相比，强迫症患者的ERN增加，但侧翼任务准确性和ΔPe降低。与健康对照相比，抽动相关和非抽动相关的强迫症患者的这些差异也很显著。在强迫症患者中，较低的ΔPe与强迫症症状发作的较早年龄相关。结果支持了强迫症涉及错误监测系统缺陷的假设，并表明较低的ΔPe可能会损害错误信号传递，并导致对反应正确性的不确定性。
