Institute for Systems Genomics, University of Connecticut, Storrs, CT, 06269, USA.
School of BioSciences, The University of Melbourne, Melbourne, VIC, 3010, Australia.
Commun Biol. 2024 May 25;7(1):636. doi: 10.1038/s42003-024-06251-0.
The eastern quoll (Dasyurus viverrinus) is an endangered marsupial native to Australia. Since the extirpation of its mainland populations in the 20th century, wild eastern quolls have been restricted to two islands at the southern end of their historical range. Eastern quolls are the subject of captive breeding programs and attempts have been made to re-establish a population in mainland Australia. However, few resources currently exist to guide the genetic management of this species. Here, we generated a reference genome for the eastern quoll with gene annotations supported by multi-tissue transcriptomes. Our assembly is among the most complete marsupial genomes currently available. Using this assembly, we infer the species' demographic history, identifying potential evidence of a long-term decline beginning in the late Pleistocene. Finally, we identify a deletion at the ASIP locus that likely underpins pelage color differences between the eastern quoll and the closely related Tasmanian devil (Sarcophilus harrisii).
东部袋狸（Dasyurus viverrinus）是一种原产于澳大利亚的濒危有袋动物。自 20 世纪其大陆种群灭绝以来，野生东部袋狸仅限于其历史分布范围南端的两个岛屿。东部袋狸是圈养繁殖计划的对象，并且已经尝试在澳大利亚大陆重新建立种群。然而，目前几乎没有资源可以指导该物种的遗传管理。在这里，我们生成了东部袋狸的参考基因组，并通过多组织转录组支持基因注释。我们的组装是目前可用的最完整的有袋动物基因组之一。使用这个组装，我们推断了该物种的种群历史，发现了在更新世晚期开始的长期下降的潜在证据。最后，我们确定了 ASIP 基因座的缺失，这可能是东部袋狸和密切相关的袋獾（Sarcophilus harrisii）之间皮毛颜色差异的基础。
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