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肥胖与中老年人群血脂异常患病率的关系:一项观察性研究。

Association between obesity and the prevalence of dyslipidemia in middle-aged and older people: an observational study.

机构信息

School of Public Health and Health Management, Gannan Medical University, Ganzhou, 341000, China.

School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, China.

出版信息

Sci Rep. 2024 May 25;14(1):11974. doi: 10.1038/s41598-024-62892-5.

Abstract

This study aimed to explore the link between various forms of obesity, including body mass index (BMI) and waist circumference (WC), and the risk of dyslipidemia among Chinese residents. We selected the study population through a multi-stage random sampling method from permanent residents aged 35 and older in Ganzhou. Obesity was categorized as non-obesity, general obesity, central obesity, or compound obesity according to established diagnostic criteria. We employed a logistic regression model to assess the relationship between different types of obesity and the risk of dyslipidemia. Additionally, we used the restricted cubic spline model to analyze the association between BMI, WC, and the risk of dyslipidemia. The study included 2030 residents aged 35 or older from Ganzhou, China. The prevalence of dyslipidemia was found to be 39.31%, with an age-standardized prevalence of 36.51%. The highest prevalence of dyslipidemia, 58.79%, was observed among those with compound obesity. After adjusting for confounding factors, we found that the risk of dyslipidemia in those with central and compound obesity was respectively 2.00 (95% CI 1.62-2.46) and 2.86 (95% CI 2.03-4.03) times higher than in the non-obese population. Moreover, the analysis using the restricted cubic spline model indicated a nearly linear association between BMI, WC, and the risk of dyslipidemia. The findings emphasize the significant prevalence of both dyslipidemia and obesity among adults aged 35 and above in Ganzhou, China. Notably, individuals with compound obesity are at a substantially increased risk of dyslipidemia. Therefore, it is crucial to prioritize the use of BMI and WC as screening and preventive measures for related health conditions.

摘要

本研究旨在探讨中国居民中各种形式的肥胖(包括体重指数(BMI)和腰围(WC))与血脂异常风险之间的联系。我们通过多阶段随机抽样方法从赣州的 35 岁及以上常住居民中选择研究人群。根据既定的诊断标准,将肥胖分为非肥胖、一般肥胖、中心性肥胖或复合性肥胖。我们采用逻辑回归模型评估不同类型肥胖与血脂异常风险之间的关系。此外,我们还采用受限立方样条模型分析 BMI、WC 与血脂异常风险之间的关联。该研究纳入了来自中国赣州的 2030 名 35 岁及以上的居民。结果发现,血脂异常的患病率为 39.31%,年龄标准化患病率为 36.51%。复合性肥胖者血脂异常的患病率最高,为 58.79%。在调整了混杂因素后,我们发现中心性肥胖和复合性肥胖者发生血脂异常的风险分别是非肥胖者的 2.00(95%CI 1.62-2.46)和 2.86(95%CI 2.03-4.03)倍。此外,受限立方样条模型的分析表明,BMI 和 WC 与血脂异常风险之间存在近乎线性的关联。研究结果强调了中国赣州 35 岁及以上成年人中血脂异常和肥胖的显著流行率。特别是,复合性肥胖者发生血脂异常的风险显著增加。因此,优先使用 BMI 和 WC 作为相关健康状况的筛查和预防措施至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7edf/11127928/aabc448bf532/41598_2024_62892_Fig1_HTML.jpg

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