Miller D, Wadsworth J, Diamond J, Ross E
Dev Biol Stand. 1985;61:389-94.
The National Childhood Encephalopathy Study received reports on 1182 cases of serious acute neurological illnesses in children admitted to hospital in Britain. The frequency of risk factors in cases was compared with matched controls. A personal or family history of convulsions was found significantly more often in cases than in controls, but no such excess was found for a history of allergy. Case children were significantly more likely to have received diphtheria, tetanus and pertussis (DTP) vaccine within seven days before onset and to have a history of whooping cough during the month of onset. The risk of serious acute brain conditions after the disease was more than six times that of three doses of DTP. In addition, there is evidence that deaths attributed to whooping cough may seriously underestimate the number associated with pertussis infection.
全国儿童脑病研究收到了关于英国住院儿童中1182例严重急性神经疾病病例的报告。将病例中的风险因素出现频率与匹配的对照组进行了比较。发现病例中个人或家族惊厥史的出现频率显著高于对照组，但过敏史则未发现此类异常。病例儿童在发病前七天内接受白喉、破伤风和百日咳（DTP）疫苗的可能性显著更高，且在发病当月有百日咳病史。患病后出现严重急性脑部疾病的风险是接种三剂DTP疫苗后风险的六倍多。此外，有证据表明，归因于百日咳的死亡人数可能严重低估了与百日咳感染相关的死亡人数。
