Department of Laboratory Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, China.
Shanghai Pudong New District Zhoupu Hospital, Shanghai 200120, China.
Diagn Microbiol Infect Dis. 2024 Aug;109(4):116375. doi: 10.1016/j.diagmicrobio.2024.116375. Epub 2024 May 23.
We described a case of a 24-year-old man with multiple organ failure caused by Fusobacterium necrophorum subsp. funduliforme F1260. This is the first described case of Lemierre's syndrome with multiple organ failure due to F. necrophorum subsp. funduliforme F1260 in an adult in China. Our study highlights that there may be a risk of misdiagnosis based solely on typical manifestations of internal jugular vein thrombophlebitis, metastatic lesions, and F. necrophorum isolated from blood cultures or normally sterile sites. Clinicians should be cognizant of the potential utility of metagenomic next-generation sequencing in facilitating early pathogen detection in severe infections, thus enabling timely and appropriate administration of antibiotics to reduce mortality rates and improve prognosis.
我们描述了一例由坏死梭杆菌亚种 F1260 引起的 24 岁男性多器官功能衰竭。这是首例在中国成人因坏死梭杆菌亚种 F1260 引起的莱姆病综合征合并多器官功能衰竭的病例。我们的研究强调，仅基于典型的颈内静脉血栓性静脉炎、转移性病变和从血液培养物或正常无菌部位分离出的坏死梭杆菌的表现，可能存在误诊的风险。临床医生应认识到宏基因组下一代测序在促进严重感染早期病原体检测中的潜在作用，从而能够及时和适当的给予抗生素，降低死亡率并改善预后。
