Department of Clinical Laboratory, the Second Hospital of Jilin University, Changchun, China.
The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Pathol Res Pract. 2024 Jul;259:155353. doi: 10.1016/j.prp.2024.155353. Epub 2024 May 16.
Ferroptosis is a novel type of iron-dependent programmed cell death characterised by intracellular iron overload, increased lipid peroxidation and abnormal accumulation of reactive oxygen species.It has been implicated in the progression of several diseases including cancer, ischaemia-reperfusion injury, neurodegenerative diseases and liver disease. The etiology of endometriosis (EMS) is still unclear and is associated with multiple factors, often accompanied by various forms of cell death and a complex microenvironment. In recent decades, the role of non-traditional forms of cell death, represented by ferroptosis, in endometriosis has come to the attention of researchers. This article reviews the transitional role of iron homeostasis in the development of ferroptosis, the characteristics and regulatory mechanisms of ferroptosis, and focuses on summarising the links between iron death and various pathogenic mechanisms of EMS, including oxidative stress, dysregulation of lipid metabolism, inflammation, autophagy and epithelial-mesenchymal transition. The possible applications of ferroptosis in the treatment of EMS, future research directions and current issues are discussed with the aim of providing new ideas for further understanding of EMS.
铁死亡是一种新型的铁依赖性程序性细胞死亡方式，其特征为细胞内铁过载、脂质过氧化增加和活性氧物种的异常积累。它与多种疾病的进展有关，包括癌症、缺血再灌注损伤、神经退行性疾病和肝脏疾病。子宫内膜异位症（EMS）的病因尚不清楚，与多种因素有关，常伴有多种形式的细胞死亡和复杂的微环境。近几十年来，以铁死亡为代表的非传统形式的细胞死亡在子宫内膜异位症中的作用引起了研究人员的关注。本文综述了铁稳态在铁死亡发生发展中的转导作用、铁死亡的特征和调控机制，并重点总结了铁死亡与 EMS 各种发病机制之间的联系，包括氧化应激、脂质代谢失调、炎症、自噬和上皮间质转化。讨论了铁死亡在 EMS 治疗中的可能应用、未来的研究方向和当前存在的问题，以期为进一步理解 EMS 提供新的思路。
