Flavor and Fragrance Engineering & Technology Research Center of Henan Province, College of Tobacco Science, Henan Agricultural University, Zhengzhou 450002, China.
Jilin Tobacco Industry Co., Ltd, No. 795 Tianchi Road, Yanji 136202, China.
Int J Biol Macromol. 2024 Jun;271(Pt 2):132663. doi: 10.1016/j.ijbiomac.2024.132663. Epub 2024 May 24.
This study investigated the release of aromatic compounds with distinct functional groups within bilayer microcapsules. Bilayer microcapsules of four distinctive core materials (benzyl alcohol, eugenol, cinnamaldehyde, and benzoic acid) were synthesized via freeze-drying. Chitosan (CS) and sodium alginate (ALG) were used as wall materials. CS concentration, using orthogonal experiments with the loading ratio as a metric. Under optimal conditions, three other types of microcapsules (cinnamic aldehyde, benzoic acid, and benzyl alcohol) were obtained. The four types of microcapsules were characterized using Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscope (TEM), and thermogravimetric analysis (TGA), and their sustained release characteristics were evaluated. The optimal conditions were: CS dosage, 1.2 %; CS-to-eugenol mass ratio, 1:2; and CS-to-ALG mass ratio, 1:1. By comparing the IR spectra of the four types of microcapsules, wall material, and core material, the core materials were revealed to be encapsulated within the wall material. SEM results revealed that the granular protuberances on the surface of the microcapsules were closely aligned and persistent when magnified 2000×. The TEM results indicated that all four microcapsules had a spherical and bilayer structure. The thermal stability and sustained release results showed that the four microcapsules were more resilient and less volatile than the four core materials. The release conformed to first-order kinetics, and the release ratios of the four microcapsules were as follows: benzyl alcohol microcapsules ˃ eugenol microcapsules ˃ cinnamaldehyde microcapsules ˃ benzoic acid microcapsules. The prepared bilayer microcapsules encapsulated four different core materials with good sustained release properties.
本研究考察了双层微胶囊中具有不同官能团的芳香族化合物的释放情况。通过冷冻干燥法合成了四种不同核心材料（苯甲醇、丁香酚、肉桂醛和苯甲酸）的双层微胶囊。壳聚糖（CS）和海藻酸钠（ALG）用作壁材。使用正交实验，以负载比为指标，考察了 CS 浓度。在最佳条件下，得到了另外三种类型的微胶囊（肉桂醛、苯甲酸和苯甲醇）。采用傅里叶变换红外（FTIR）光谱、扫描电子显微镜（SEM）、透射电子显微镜（TEM）和热重分析（TGA）对四种类型的微胶囊进行了表征，并评价了其缓释特性。最佳条件为：CS 用量为 1.2%；CS 与丁香酚的质量比为 1:2；CS 与 ALG 的质量比为 1:1。通过比较四种类型的微胶囊、壁材和芯材的红外光谱，发现芯材被包裹在壁材中。SEM 结果表明，当放大 2000 倍时，微胶囊表面的颗粒状突起排列紧密且连续。TEM 结果表明，四种微胶囊均具有球形双层结构。热稳定性和缓释结果表明，四种微胶囊比四种芯材更有弹性、挥发性更小。释放符合一级动力学，四种微胶囊的释放比例如下：苯甲醇微胶囊＞丁香酚微胶囊＞肉桂醛微胶囊＞苯甲酸微胶囊。本研究制备了四种不同芯材的双层微胶囊，具有良好的缓释性能。
