Lima Caroline Santos Alves de, Varca Gustavo Henrique Costa, Costa Sirlene Maria da, Ferraz Humberto Gomes, Santos Ana Carolina da Silva, Lopes Patrícia Santos, Costa Silgia Aparecida da
School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.
Nuclear and Energy Research Institute, IPEN-CNEN/SP, São Paulo, Brazil.
Drug Dev Ind Pharm. 2020 Sep;46(9):1477-1486. doi: 10.1080/03639045.2020.1809445. Epub 2020 Aug 21.
The goal of this work was the development of natural polymeric microcapsules for antimicrobial drug delivery - triclosan loaded alginate and chitosan-based microcapsules for potential coating applications in substrates such as textiles or plastics. Microcapsules containing 2.5% (w/w) or 3% (w/w) triclosan in both core and matrix were synthesized and evaluated by Fourier-transform infrared spectroscopy, scanning electron microscopy, confocal microscopy, differential scanning calorimetry, thermogravimetry, and antimicrobial activity. The microcapsules produced featured spherical and mostly irregularly-shaped surfaces composed by an alginate core in a chitosan outer matrix, as revealed by confocal microscopy, and antimicrobial activity against and with inhibition halos up to 60 mm and 25 mm respectively, granted by a triclosan loading of 61.66%. The thermal analysis suggested that the polymers protected the active substance from temperature-induced degradation. In conclusion, these microcapsules may be applied toward antimicrobial functionalization of plastics, textiles and other materials.
这项工作的目标是开发用于抗菌药物递送的天然聚合物微胶囊——负载三氯生的藻酸盐和壳聚糖基微胶囊，用于在纺织品或塑料等基材上的潜在涂层应用。合成了核心和基质中均含有2.5%（w/w）或3%（w/w）三氯生的微胶囊，并通过傅里叶变换红外光谱、扫描电子显微镜、共聚焦显微镜、差示扫描量热法、热重分析法和抗菌活性进行了评估。共聚焦显微镜显示，所制备的微胶囊具有球形且大多形状不规则的表面，由壳聚糖外层基质中的藻酸盐核心组成，三氯生负载量为61.66%，对金黄色葡萄球菌和大肠杆菌具有抗菌活性，抑菌圈分别高达60毫米和25毫米。热分析表明，聚合物保护了活性物质免受温度诱导的降解。总之，这些微胶囊可用于塑料、纺织品和其他材料的抗菌功能化。
