College of Life and Environmental Sciences, University of Exeter, Penryn Campus, Cornwall, UK.
College of Life and Environmental Sciences, University of Exeter, Penryn Campus, Cornwall, UK.
Trends Microbiol. 2024 Nov;32(11):1060-1071. doi: 10.1016/j.tim.2024.05.001. Epub 2024 May 25.
Ignoring the dynamic nature of microbial communities risks underestimating the power of microbes to impact the health of their hosts. Microbiomes are thought to be important for host fitness, yet the coarse temporal scale and population-level focus of many studies precludes the ability to investigate the importance of among-individual variation in stability and identify the ecological contexts in which this variation matters. Here we briefly summarise current knowledge of temporal dynamics in wild host-associated microbial communities. We then discuss the implications of among-individual variation in microbiota stability and suggest analytical approaches for understanding these patterns. One major requirement is for future studies to conduct individual-level longitudinal analyses, with some systems already well set up for answering these questions.
忽略微生物群落的动态性质可能会低估微生物对宿主健康产生影响的能力。微生物组被认为对宿主的适应性很重要，但由于许多研究的时间尺度粗糙，并且侧重于群体水平，因此无法研究个体间稳定性变化的重要性，也无法确定这种变化在哪些生态环境中起作用。在这里，我们简要总结了野生宿主相关微生物群落中时间动态的现有知识。然后，我们讨论了微生物群落稳定性个体间变化的意义，并提出了用于理解这些模式的分析方法。一个主要要求是未来的研究要进行个体水平的纵向分析，有些系统已经为回答这些问题做好了准备。
