Aomori Agricultural Mutual Aid Association, Aomori, Japan.
Hokkaido Agricultural Mutual Aid Association, Hokkaido, Japan.
J Vet Med Sci. 2024 Jul 2;86(7):721-726. doi: 10.1292/jvms.24-0089. Epub 2024 May 27.
The present study investigated the prevalence of blood chloride (Cl) abnormalities in diarrheic neonatal calves with metabolic acidosis and attempted to identify the most relevant electrolyte abnormality to these abnormalities. A retrospective analysis was conducted on the medical records of 157 diarrheic neonatal calves aged 10.3 ± 4.2 days old with metabolic acidosis. Hypochloremia, normochloremia, and hyperchloremia were observed in 8.9% (14/157), 43.3% (68/157), and 47.8% (68/157), respectively, of diarrheic calves with metabolic acidosis. This distribution remained similar regardless of age (under 8 days or 8 days and older). Furthermore, a multiple logistic regression analysis showed that variations in values for blood sodium [Na (regression coefficients 0.877; 95% confidence interval (CI) 13.977-134.195; P<0.01)], pH (regression coefficients -10.719; 95% CI -19.076- -2.362; P<0.05), and bicarbonate [HCO (regression coefficients -0.555; 95% CI -0.820- -0.290; P<0.01)] were associated with blood Cl abnormalities. The present results revealed that blood Na concentrations were more strongly associated with blood Cl concentrations than blood pH and HCO values. In the present study, diarrheic calves with hyperchloremia were characterized by normonatremia and extremely severe metabolic acidosis.
本研究调查了伴有代谢性酸中毒的腹泻新生犊牛的血氯（Cl）异常发生率，并试图确定与这些异常最相关的电解质异常。对 157 例年龄为 10.3 ± 4.2 天伴有代谢性酸中毒的腹泻新生犊牛的病历进行了回顾性分析。患有代谢性酸中毒的腹泻犊牛中，低氯血症、正常氯血症和高氯血症的发生率分别为 8.9%（14/157）、43.3%（68/157）和 47.8%（68/157）。无论年龄（<8 天或≥8 天）如何，这种分布都保持相似。此外，多元逻辑回归分析显示，血钠值的变化[Na（回归系数 0.877；95%置信区间（CI）13.977-134.195；P<0.01）]、pH（回归系数-10.719；95%CI-19.076- -2.362；P<0.05）和碳酸氢盐[HCO（回归系数-0.555；95%CI-0.820- -0.290；P<0.01）]与血 Cl 异常相关。本研究结果表明，血 Na 浓度与血 Cl 浓度的相关性强于血 pH 和 HCO 值。在本研究中，高氯血症的腹泻犊牛表现为正常血钠和极其严重的代谢性酸中毒。
