White Brooke, Sirohi Sunil
Laboratory of Endocrine and Neuropsychiatric Disorders, Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA.
Curr Pharm Des. 2024;30(23):1822-1837. doi: 10.2174/0113816128292367240510111746.
Approximately 16.5% of the United States population met the diagnostic criteria for substance use disorder (SUD) in 2021, including 29.5 million individuals with alcohol use disorder (AUD). Individuals with AUD are at increased risk for malnutrition, and impairments in nutritional status in chronic alcohol users can be detrimental to physical and emotional well-being. Furthermore, these nutritional deficiencies could contribute to the never-ending cycle of alcoholism and related pathologies, thereby jeopardizing the prospects of recovery and treatment outcomes. Improving nutritional status in AUD patients may not only compensate for general malnutrition but could also reduce adverse symptoms during recovery, thereby promoting abstinence and successful treatment of AUD. In this review, we briefly summarize alterations in the nutritional status of people with addictive disorders, in addition to the underlying neurobiological mechanisms and clinical implications regarding the role of nutritional intervention in recovery from alcohol use disorder.
2021年，约16.5%的美国人口符合物质使用障碍（SUD）的诊断标准，其中包括2950万患有酒精使用障碍（AUD）的个体。患有AUD的个体营养不良风险增加，慢性酒精使用者的营养状况受损会对身心健康有害。此外，这些营养缺乏可能导致酗酒和相关病症的恶性循环，从而危及康复前景和治疗效果。改善AUD患者的营养状况不仅可以弥补一般营养不良，还可以减少康复期间的不良症状，从而促进戒酒和AUD的成功治疗。在本综述中，我们简要总结了成瘾性障碍患者营养状况的改变，以及营养干预在酒精使用障碍康复中的作用的潜在神经生物学机制和临床意义。
