Serrano Maitane, Rico-Barrio Irantzu, Grandes Pedro
Laboratory of Ultrastructural and Functional Neuroanatomy of the Synapse, Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.
Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.
Front Nutr. 2023 Apr 5;10:1068343. doi: 10.3389/fnut.2023.1068343. eCollection 2023.
Alcohol is the most widely consumed psychoactive substance in the world that has a severe impact on many organs and bodily systems, particularly the liver and nervous system. Alcohol use during pregnancy roots long-lasting changes in the newborns and during adolescence has long-term detrimental effects especially on the brain. The brain contains docosahexaenoic acid (DHA), a major omega-3 (n-3) fatty acid (FA) that makes up cell membranes and influences membrane-associated protein function, cell signaling, gene expression and lipid production. N-3 is beneficial in several brain conditions like neurodegenerative diseases, ameliorating cognitive impairment, oxidative stress, neuronal death and inflammation. Because alcohol decreases the levels of n-3, it is timely to know whether n-3 supplementation positively modifies alcohol-induced injuries. The aim of this review is to summarize the state-of-the-art of the n-3 effects on certain conditions caused by alcohol intake, focusing primarily on brain damage and alcoholic liver disease.
酒精是世界上消费最为广泛的精神活性物质，它对许多器官和身体系统都有严重影响，尤其是肝脏和神经系统。孕期饮酒会给新生儿带来长期影响，而青春期饮酒则具有长期有害作用，特别是对大脑。大脑含有二十二碳六烯酸（DHA），这是一种主要的ω-3（n-3）脂肪酸（FA），它构成细胞膜并影响与膜相关的蛋白质功能、细胞信号传导、基因表达和脂质生成。n-3对多种脑部疾病有益，如神经退行性疾病，可改善认知障碍、氧化应激、神经元死亡和炎症。由于酒精会降低n-3的水平，因此了解补充n-3是否能积极改善酒精所致损伤很有必要。本综述的目的是总结n-3对酒精摄入所致某些状况的影响的最新研究进展，主要关注脑损伤和酒精性肝病。
