1,25-二羟维生素D3对细胞因子诱导的胸腺细胞增殖的影响。

Effect of 1,25-dihydroxyvitamin D3 on cytokine-induced thymocyte proliferation.

作者信息

Koizumi T, Nakao Y, Matsui T, Nakagawa T, Katakami Y, Fujita T

出版信息

Cell Immunol. 1985 Dec;96(2):455-61. doi: 10.1016/0008-8749(85)90377-6.

Abstract

To clarify the mechanism of the inhibitory effect of 1,25(OH)2D3 on lymphocyte proliferation, the effect of 1,25(OH)2D3 on murine thymocyte proliferation induced by interleukin 1 (IL-1), or 2 (IL-2) was examined. Physiological concentrations of 1,25(OH)2D3 inhibited thymocyte proliferation induced by IL-1 and IL-2 in similar fashion suggesting an inhibition of the response to IL-2 by this hormone. In addition, cortisone-resistant thymocytes (including a majority of medullary thymocytes), which proliferate more vigorously in response to IL-1 than do untreated thymocytes, were more sensitive to 1,25(OH)2D3 inhibition. Therefore, the inhibition of IL-2 production of the mature medullary thymocyte by this hormone was also suggested.

摘要

为阐明1,25(OH)₂D₃对淋巴细胞增殖的抑制作用机制，研究了1,25(OH)₂D₃对白细胞介素1（IL-1）或白细胞介素2（IL-2）诱导的小鼠胸腺细胞增殖的影响。生理浓度的1,25(OH)₂D₃以类似方式抑制IL-1和IL-2诱导的胸腺细胞增殖，提示该激素抑制对IL-2的反应。此外，对可的松耐药的胸腺细胞（包括大多数髓质胸腺细胞），与未处理的胸腺细胞相比，对IL-1反应时增殖更旺盛，对1,25(OH)₂D₃的抑制更敏感。因此，也提示该激素抑制成熟髓质胸腺细胞产生IL-2。