Wang Huaishi, Zhang Lihai, Hu Chao, Li Hui, Jiang Mingyan
Department of Pulmonary and Critical Care Medicine, Xiangtan Central Hospital, Xiangtan, Hunan 411100, P.R. China.
Mol Clin Oncol. 2024 May 15;21(1):45. doi: 10.3892/mco.2024.2743. eCollection 2024 Jul.
Wnt signaling is a highly conserved evolutionary pathway that plays a key role in regulation of embryonic development, as well as tissue homeostasis and regeneration. Abnormalities in Wnt signaling are associated with tumorigenesis and development, leading to poor prognosis in patients with cancer. However, the pharmacological effects and mechanisms underlying Wnt signaling and its inhibition in cancer treatment remain unclear. In addition, potential side effects of inhibiting this process are not well understood. Therefore, the present review outlines the role of Wnt signaling in tumorigenesis, development, metastasis, cancer stem cells, radiotherapy resistance and tumor immunity. The present review further identifies inhibitors that target Wnt signaling to provide a potential novel direction for cancer treatment. This may facilitate early application of safe and effective drugs targeting Wnt signaling in clinical settings. An in-depth understanding of the mechanisms underlying inhibition of Wnt signaling may improve the prognosis of patients with cancer.
Wnt信号通路是一条高度保守的进化途径，在胚胎发育的调控以及组织稳态和再生中起着关键作用。Wnt信号通路异常与肿瘤发生和发展相关，导致癌症患者预后不良。然而，Wnt信号通路及其抑制在癌症治疗中的药理作用和机制仍不清楚。此外，抑制这一过程的潜在副作用也尚未得到充分了解。因此，本综述概述了Wnt信号通路在肿瘤发生、发展、转移、癌症干细胞、放疗抵抗和肿瘤免疫中的作用。本综述进一步鉴定了靶向Wnt信号通路的抑制剂，为癌症治疗提供了潜在的新方向。这可能有助于在临床环境中早期应用针对Wnt信号通路的安全有效药物。深入了解抑制Wnt信号通路的机制可能会改善癌症患者的预后。
